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REVIEWS  CELL LABELING 

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2005 December;49(4):304-7

Copyright © 2009 EDIZIONI MINERVA MEDICA

lingua: Inglese

A brief history of cell labelling

Peters A. M.

School of Applied Physiology Brighton and Sussex Medical School, Brighton, UK


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The term cell labelling is usually used in the context of labelled leukocytes for imaging inflammation and labelled platelets for imaging thrombosis. Erythrocyte labelling for in vitro measurements of red cell life span, in vivo measurements of splenic red cell pooling, radionuclide ventriculography and imaging sites of bleeding has developed rather separately and has a different history. Labelled platelets and leukocytes were originally developed for cell kinetic studies. Since the current-day applications of labelled platelets and leukocytes depend on a clear understanding of cell kinetics, these classical studies are important and relevant to the history of cell labelling.

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