![]() |
JOURNAL TOOLS |
eTOC |
Per abbonarsi |
Sottometti un articolo |
Segnala alla tua biblioteca |
ARTICLE TOOLS |
Estratti |
Permessi |

I TUOI DATI
I TUOI ORDINI
CESTINO ACQUISTI
N. prodotti: 0
Totale ordine: € 0,00
COME ORDINARE
I TUOI ABBONAMENTI
I TUOI ARTICOLI
I TUOI EBOOK
COUPON
ACCESSIBILITÀ
USE OF RADIOLABELLED PEPTIDES FOR SCINTIGRAPHY IN NON-ONCOLOGIC DISEASES
The Quarterly Journal of Nuclear Medicine 2003 December;47(4):349-61
Copyright © 2009 EDIZIONI MINERVA MEDICA
lingua: Inglese
The role of labeled Annexin A5 in imaging of programmed cell death. From animal to clinical imaging
Kietselaer B. L. J. H. 1, Hofstra L. 1, Dumont E. A. W. 1, Reutelingsperger C. P. M. 2, Heidendal G. A. K. 3
1 Department of Cardiology University Hospital of Maastricht, Maastricht, The Netherlands 2 Department of Biochemistry University of Maastricht, Maastricht, The Netherlands 3 Department of Nuclear Medicine University Hospital of Maastricht, Maastricht, The Netherlands
Programmed cell death plays a critical role in embryology, homeostasis and disease. However, until recently no non-invasive imaging modality has been able to visualize this process directly. Annexin A5 binds to cells undergoing programmed cell death. When labeling this protein, Annexin A5 becomes a tool for the detection of programmed cell death in vitro and in vivo. Labeled Annexin A5 has enabled our group and others to detect programmed cell death non-invasively in animals and patients. This review will highlight the development of this imaging modality in cellular and animal models. Furthermore, we will discuss Annexin A5 imaging in human disease. We will focus on the clinical applications and their relevance, limitations and future perspectives of non-invasive imaging of programmed cell death using labeled Annexin A5.