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NOVEL METHODS OF ALTERING PHARMACOKINETICS IN RADIOPHARMACEUTICAL DESIGN
Guest Editor: Hnatowich D.
The Quarterly Journal of Nuclear Medicine 2002 September;46(3):171-80
Copyright © 2009 EDIZIONI MINERVA MEDICA
lingua: Inglese
Polyethylene glycol in the design of tumor-targetting radiolabelled macromolecules - lessons from liposomes and monoclonal antibodies
Harrington K. J. 1, Mubashar M. 2, Peters A. M. 2
1 Cancer Research UK Laboratory of Targetted Therapy Centre for Cell and Molecular Biology Institute of Cancer Research, London, UK 2 Department of Nuclear Medicine, Addenbrooke’s Hospital Cambridge, UK
Radiolabelled macromolecules such as liposomes and monoclonal antibodies (Mab) are attractive agents for tumour-targetting studies. In addition to their potential diagnostic role, they can also provide vital information on the targetting capacity of therapeutic agents. Certainly in the case of liposome development, this ability to track the pharmacokinetics and biodistribution of the agents in a non-invasive fashion has assisted the design and application of therapeutic liposomal agents. A significant limitation of unmodified liposomes and Mab is their tendency to be cleared rapidly from the circulation. The use of polyethylene glycol (PEG) in the formulation of these agents has the capacity to alter their biological behaviour in such a way as to improve their ability to target tumours. In this paper we review the data relating to the use of PEG-modified liposomes and Mab in the context of nuclear medicine studies.