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ORIGINAL ARTICLES  NEU­RO­PHAR­MA­COL­O­GY 

The Quarterly Journal of Nuclear Medicine 1998 September;42(3):158-65

Copyright © 2000 EDIZIONI MINERVA MEDICA

lingua: Inglese

Special issues in quantitation of brain receptors and related markers by emission computed tomography

Links J. M.

From the Radiology and Radiological Science Johns Hopkins University, Baltimore, MD, USA


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Emis­sion com­puted tomog­raphy pro­vides an oppor­tu­nity to quan­tify neu­ro­trans­mitter-neu­ro­re­ceptor ­systems in ­vivo. In ­order to do so, ­very ­high ­image ­quality and quan­ti­ta­tive accu­racy are ­required. Quan­ti­ta­tion of ­receptor ­systems ­involves con­sid­er­a­tions of phys­ical ­effects (­such as ­finite spa­tial res­o­lu­tion, ­scatter, and atten­u­a­tion), instru­men­ta­tion ­design (­such as spa­tial sam­pling), ­image pro­cessing (­such as fil­tering), and ­data anal­ysis (­such as ­kinetic mod­eling). Appro­priate appli­ca­tion of ­these con­sid­er­a­tions can ­lead to ­useful ­results, but ­emerging ­approaches ­promise ­even ­greater ­levels of accu­racy and pre­ci­sion.

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