Journal of Neurosurgical Sciences 2019 Jul 11

DOI: 10.23736/S0390-5616.19.04735-0

Copyright © 2019 EDIZIONI MINERVA MEDICA

lingua: Inglese

Intraoperative Computed Tomography, navigated ultrasound, 5-Amino-Levulinic Acid fluorescence and neuromonitoring in brain tumor surgery: overtreatment or useful tool combination?

Giuseppe BARBAGALLO ^{1, 5} ✉, Massimiliano MAIONE ¹, Simone PESCHILLO ^{1, 5}, Francesco SIGNORELLI ², Massimiliano VISOCCHI ^{3, 4}, Giuseppe SORTINO ⁵, Giuseppa FIUMANÒ ⁵, Francesco CERTO ^{1, 5}

¹ Department of Neurological Surgery, Policlinico “G. Rodolico” University Hospital, Catania, Italy; ² Department of Neurosurgery, Policlinico di Bari University Hospital, Bari, Italy; ³ Institute of Neurosurgery, Catholic University, Rome, Italy; ⁴ Department of Radiodiagnostic and Oncological Radiotherapy, University Hospital Policlinico-Vittorio Emanuele, Catania, Italy; ⁵ Interdisciplinary Research Center on Brain Tumors Diagnosis and Treatment, University of Catania, Catania, Italy

BACKGROUND: Brain tumor surgery is routinely supported by several intraoperative techniques, such as fluorescence, brain mapping and neuronavigation, which are often used independently. Efficacy of navigation is limited by the brain-shift phenomenon, particularly in cases of large or deep-sited lesions. Intraoperative imaging was introduced also to update neuronavigation data, to try and solve the brain-shift phenomenon-related pitfalls and increase overall safety. Nevertheless, each intraoperative imaging modality has some intrinsic limitations and technical shortcomings, making its clinical use challenging. We used a multimodal intraoperative imaging protocol to update neuronavigation, based on the combination of intraoperative Ultrasound (i-US) and intraoperative Computed Tomography (i-CT) integrated with 5-ALA fluorescence and neuromonitoring-guided resection.
METHODS: This is a pilot study on 52 patients (29 men), including four children, with a mean age of 57.67 years, suffering from brain low- (10 patients) or high-grade (34 patients) glioma or metastasis (8 patients), prospectively and consecutively enrolled. They underwent 5-ALA fluorescence-guided microsurgical tumor resection and neuromonitoring was used in cases of lesions located in eloquent areas, according to pre-operative clinical and neuroradiological features. Navigated B-mode ultrasound acquisition was carried out after dural opening to identify the lesion. After tumor resection, i-US was used to identify residual tumor. Following further tumor resection or in cases of unclear US images, post-contrast i-CT was performed to detect and localize small tumor remnants and to allow further correction for brain shift. A final i-US check was performed to verify the completeness of resection. Clinical evaluation was based on comparison of pre- and post-operative Karnofsky Performance Score (KPS) and assessment of Overall Survival (OS) and Progression Free Survival (PFS). Extent of tumor resection (EOTR) was evaluated by volumetric post-operative Magnetic Resonance performed within 48 h after surgery.
RESULTS: Forty-one of the 52 (78.8%) patients were alive and still under follow-up in December 2017. 5-ALA was strongly or vaguely positive in 45 cases (86.5%). Seven lesions (4 low-grade glioma, 1 high-grade glioma and 2 metastases) were not fluorescent. i-US visualized residual tumor after resection of all fluorescent or pathological tissue in 22 cases (42.3%). After i-US guided resection, i-CT documented the presence of further residual tumor in 11 cases (21.1%). Mean EOTR was 98.79% in the low-grade gliomas group, 99.84% in the high-grade gliomas group and 100% in the metastases group. KPS changed from 77.88, pre-operatively, to 72.5, post-operatively. At the last follow-up, mean KPS was 84.23.
CONCLUSIONS: The combination of different intraoperative imaging modalities may increase brain tumor safety and extent of resection. In particular, i-US seems to be highly sensitive to detect residual tumors, but it may generate false positives due to artifacts. Conversely, i-CT is more specific to localize remnants, allowing a more reliable updating of navigation data.

KEY WORDS: Intraoperative imaging guidance; i-CT; i-US; 5-ALA fluorescence; Neuromonitoring