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JOURNAL OF NEUROSURGICAL SCIENCES

Rivista di Neurochirurgia


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Journal of Neurosurgical Sciences 2018 Feb 23

DOI: 10.23736/S0390-5616.18.04258-3

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Relationship between pineal cyst size and aqueductal CSF flow measured by phase contrast MRI

Abraham F. BEZUIDENHOUT 1 , Ekkehard M. KASPER 2, Olivier BALEDENT 3, Rafael ROJAS 1, Rafeeque A. BHADELIA 1

1 Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 2 Department of Neurosurgery, Beth Israel Deaconess Medical Center, Boston, MA, USA; 3 Department of Imaging and Biophysics, CHU Nord, Amiens, France


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BACKGROUND: Most patients with pineal cysts referred for neurosurgical consultation have no specific symptoms or objective findings except for pineal cyst size to help in management decisions. Our purpose was to assess the relationship between pineal cyst size and aqueductal CSF flow using PC- MRI.
METHODS: Eleven adult patients with pineal cysts (> 1-cm in size) referred for neurosurgical consultations were included. Cyst volume was calculated using 3D T1 images. PC-MRI in axial plane with velocity encoding of 5 cm/sec was used to quantitatively assess CSF flow through the cerebral aqueduct to determine the aqueductal stroke volume, which was then correlated to cyst size using Pearson's correlation. Pineal cysts were grouped by size into small (6/11) and large (5/11) using the median value to compare aqueductal stroke volume using Mann-Whitney test.
RESULTS: Patients were 39 ± 13 years (mean ± SD) of age, and 10/11 (91%) were female. There was significant negative correlation between cyst volume and aqueductal stroke volume (r=0.74; p=0.009). Volume of small cysts (4954±2157 mm3) was significantly different compared to large cysts (13752±3738 mm3; p= 0.008). The aqueductal stroke volume of patients harboring large cysts 33±8 μL/cardiac cycle was significantly lower than that of patients with small cysts 96±29 μL/cardiac cycle (p=0.008).
CONCLUSIONS: Aqueductal CSF flow appears to decrease with increasing pineal cyst size. Our preliminary results provide first evidence that even in the absence of objective neurological findings or hydrocephalus; larger pineal cysts already display decreased CSF flow through the cerebral aqueduct.

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Publication History

Article first published online: February 23, 2018
Manuscript accepted: February 8, 2018
Manuscript revised: February 1, 2018
Manuscript received: November 1, 2017

Per citare questo articolo

Bezuidenhout AF, Kasper EM, Baledent O, Rojas R, Bhadelia R. Relationship between pineal cyst size and aqueductal CSF flow measured by phase contrast MRI. J Neurosurg Sci 2018 Feb 23. DOI: 10.23736/S0390-5616.18.04258-3

Corresponding author e-mail

abezuide@bidmc.harvard.edu