Home > Riviste > Journal of Neurosurgical Sciences > Fascicoli precedenti > Articles online first > Journal of Neurosurgical Sciences 2015 Oct 06

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti
Per citare questo articolo

JOURNAL OF NEUROSURGICAL SCIENCES

Rivista di Neurochirurgia


Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,522


eTOC

 

Journal of Neurosurgical Sciences 2015 Oct 06

Copyright © 2015 EDIZIONI MINERVA MEDICA

lingua: Inglese

Neuroprotective effects of hemicraniectomy in malign middle cerebral artery infarctions: experimental study

Altintas O. 1, Antar V. 2, Baran O. 2, Karatas E. 3, Altintas M. O. 4, Kesgin S. 3, Buyukpinarbasili N. 5, Kocyigit A. 3, Asil T. 6

1 Bor State Hospital, Department of Neurology, Bor/ Nigde /Turkey; 2 Istanbul Training and Research Hospital, Department of Neurosurgery, Kasap İlyas District. Org. Abdurrahman Nafiz, Istanbul, Turkey; 3 Bezmi Alem Vakıf University, Medical Faculty, Department of Biochemistry, Adnan Menderes Bulvarı, Fatih, Istanbul, Turkey; 4 Fatih University, Department of Genetic and Bioengineering, Buyukcekmece Campus, Buyukcekmece/İstanbul; 5 Bezmi Alem Vakıf University, Medical Faculty, Department of Pathology, Adnan Menderes Bulvarı, Fatih, Istanbul, Turkey; 6 Bezmi Alem Vakıf University, Medical Faculty, Department of Neurology, Adnan Menderes Bulvarı, Fatih, Istanbul, Turkey


PDF  


INTRODUCTION: Despite optimal medical therapy the mortality rate approaches 50% in MCA infarctions. Although recent studies have been showed life-saving effect of hemicraniectomy; there are a few data available in regard to neuroprotection effect of decompressive craniectomy (DC). We induced a malign cerebral ischemia model by intraluminal permanent middle cerebral artery occlusion (MCAo) in male rats for defining the neuroprotective effects of early DC on brain-blood barrier (BBB) molecular changes, infarct size and cerebral edema.
MATERIAL-METHOD: 48 male Spraque Dawley rats were allocated to 4 groups; sham (n = 9), control (n = 9), experiment 1 (n = 15), experiment 2 (n = 15). DC was performed by creating a bone flap, after MCAo at 4th and 24th hours. After 28 hours of survival, all animals were sacrificed. Infarction volumes were calculated from TTC (2,3,5,triphenyltetrozolium chloride)- stained brain sections. In all groups, cerebral edema was quantified as a change in the percentage (%) of brain water content. Western Blot was used to analyze the expression of tight junction protein claudin-5 and occludin.
RESULTS: Brain water content was calculated 75,18±0,75 % in the early DC group and 77,76 ± 0,71 % in the late DC group. No significant difference was found between experiment groups (p= .178). In the early DC group; occludin and claudin-5 were significantly expressed at higher levels compared to late DC group (for occludin p = .013; for claudin-5 p = .034). At early DC group (73,38±23,11 mm3) the final infarct volumes (in terms of cubic millimeters; mm3) were significantly smaller than in the late DC group (377,18±39,23 mm3) (p = .013).
CONCLUSION: The study results supported the neuroprotective effects of early DC in malign MCA infarcts.

inizio pagina

Publication History

Per citare questo articolo

Altintas O, Antar V, Baran O, Karatas E, Altintas MO, Kesgin S, et al. Neuroprotective effects of hemicraniectomy in malign middle cerebral artery infarctions: experimental study. J Neurosurg Sci 2015 Oct 06. 

Corresponding author e-mail

dr.ozgealtintas@gmail.com