Home > Riviste > Journal of Neurosurgical Sciences > Fascicoli precedenti > Journal of Neurosurgical Sciences 2020 August;64(4) > Journal of Neurosurgical Sciences 2020 August;64(4):399-403

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo

 

CASE REPORT   

Journal of Neurosurgical Sciences 2020 August;64(4):399-403

DOI: 10.23736/S0390-5616.17.04067-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Natural history of de novo high grade glioma: first description of growth parabola

Roberto ALTIERI 1 , Seiichiro HIRONO 2, Hugues DUFFAU 3, Alessandro DUCATI 1, Marco M. FONTANELLA 4, Giuseppe LA ROCCA 5, Antonio MELCARNE 1, Pier P. PANCIANI 4, Giannantonio SPENA 4, Diego GARBOSSA 1

1 Unit of Neurosurgery, Città della Salute e della Scienza, University of Turin, Turin, Italy; 2 Department of Neurosurgery, Graduate School of Medicine, Chiba University, Chiba, Japan; 3 Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France; 4 Unit of Neurosurgery, Spedali Civili and University of Brescia, Brescia, Italy; 5 Unit of Neurosurgery, School of Medicine, Sacred Heart Catholic University, Rome, Italy



Etiopathogenesis and physiopathology of gliomas are largely unknown. Recently, many authors have proved a strict correlation between the velocity of diametric expansion (VDE) on the magnetic resonance imaging (MRI) and the biological behavior of these tumors, especially in low grade gliomas (LGGs). Unfortunately, natural history of High Grade Gliomas (HGGs) has not been well clarified because of its fast progression, late diagnoses and early surgical intervention. We describe, for the first time to our knowledge, the case of asymptomatic patient with an incidentally discovered de novo HGG with a total of 17 months of follow-up. A male patient was referred to our consultation for routinely follow-up after meningioma resection 5 years before. He underwent MRI every year without any neuroradiological alterations. A new MRI image presented a non-enhancing lesion in the right temporal lobe with 3.55 cm of mean tumor diameter (MTD) and 35.6 mm/year of VDE. After two months interval, the lesion had 3.97 cm of MTD and 27.8 mm/year of VDE. Although we have strongly suggested surgical resection, patient have delayed the operation for personal issues. After other 3 months, the tumor showed enhancement with 4.5 of MTD and 17.4 mm/year of VDE. We speculate that the descending parabola is due to initial mass effect and hypoxia of the tumor core. We also underline the crucial role of the VDE determining, in order to predict the nature of the lesion and address the most effective treatment for each patient.


KEY WORDS: Glioma; Glioblastoma; Astrocytoma

inizio pagina