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JOURNAL OF NEUROSURGICAL SCIENCES

Rivista di Neurochirurgia


Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
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Journal of Neurosurgical Sciences 2018 April;62(2):203-13

DOI: 10.23736/S0390-5616.17.04230-8

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Current and future uses of transcranial focused ultrasound in neurosurgery

David S. HERSH, Howard M. EISENBERG

Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA


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Focused ultrasound (FUS) produces a region of high intensity at the focal zone of the beam but with minimal effects at adjacent areas, allowing the sonication of deep targets throughout the body. Despite early obstacles to transmitting ultrasound energy through the skull, recent advances in ultrasound technology, software, and real-time monitoring have resulted in a renewed interest in the clinical applications of transcranial FUS. Following extensive pre-clinical studies, ultrasound-induced thermal ablation has been approved by several countries for the treatment of essential tremor, Parkinson’s disease, obsessive-compulsive disorder, depression, and neuropathic pain. Ongoing clinical trials involving patients with brain tumors, Alzheimer’s disease, or epilepsy, and pre-clinical work involving stroke and hydrocephalus have the potential to significantly expand the possible indications for transcranial FUS in the future.


KEY WORDS: Ultrasonography, doppler, transcranial - Magnetic resonance imaging - Ablation techniques - Blood-brain barrier

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Publication History

Issue published online: March 14, 2018
Article first published online: November 3, 2017
Manuscript accepted: October 24, 2017
Manuscript received: October 4, 2017

Per citare questo articolo

Hersh DS, Eisenberg HM. Current and future uses of transcranial focused ultrasound in neurosurgery. J Neurosurg Sci 2018;62:203-13. DOI: 10.23736/S0390-5616.17.04230-8

Corresponding author e-mail

heisenberg@smail.umaryland.edu