Home > Riviste > Journal of Neurosurgical Sciences > Fascicoli precedenti > Journal of Neurosurgical Sciences 2017 October;61(5) > Journal of Neurosurgical Sciences 2017 October;61(5):481-5

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo

 

ORIGINAL ARTICLE   

Journal of Neurosurgical Sciences 2017 October;61(5):481-5

DOI: 10.23736/S0390-5616.16.03163-X

Copyright © 2015 EDIZIONI MINERVA MEDICA

lingua: Inglese

Should we use the serum vaspin level for the diagnosis and/or prognosis of subarachnoid hemorrhage?

Cagatay CALIKOGLU 1 , Murteza CAKIR 1, Zerrin KUTLU KOTAN 2, Gokhan OZDEMIR 3, Lutfi ÖZEL 3, Irmak FERAH 4

1 Department of Neurosurgery, Ataturk University Faculty of Medicine, Erzurum, Turkey; 2 Department of Biochemistry, Ataturk University Faculty of Pharmacy, Erzurum, Turkey; 3 Department of Neurology, Ataturk University Faculty of Medicine, Erzurum, Turkey; 4 Department of Pharmacology, Ataturk University Faculty of Medicine, Erzurum, Turkey


PDF


BACKGROUND: We aimed to investigate whether vaspin, a member of the serine protease family, could be used as a marker for the severity and prognosis of subarachnoid hemorrhage (SAH).
METHODS: Fifty-two consecutive patients (mean age, 51.46±3.2 years; 61.5% male) admitted to the emergency service of our hospital and hospitalized at our clinic with the diagnosis of aneurysmal SAH between 2012 and 2014 were included in the study and followed up for six months for outcome. The control group consisted of 52 healthy individuals of similar age and gender.
RESULTS: During the 6-month follow-up, 8 of 52 patients died, and 18 (34.6%) patients had poor the Glasgow Outcome Score (GOS) scores. In 20 (38.46%) patients, acute hydrocephalus developed, and external ventricular drainage was performed. In the study group, the mean vaspin level was significantly higher than control group (157.88±33.6 pg/mL and 109.59±45.68 pg/mL, respectively; P<0.01). The mean vaspin level was 215.18±12.36 pg/mL in the non-survival group and 147.47±24.43 pg/mL in the survival group. Furthermore, it was 195.99±21.10 pg/mL in patients with poor outcome in terms of GOS, and 137.71±17.61 pg/mL in those with good outcome. The vaspin levels significantly increased with worsening of GOS, the World Federation of Neurological Surgeons (WFNS) grading system, and Fisher scores and increasing plasma C-reactive protein levels (P<0.01 for all).
CONCLUSIONS: In conclusion, vaspin can play a role as a new marker in the diagnosis, severity assessment, and prognosis of SAH.


KEY WORDS: Biological markers - Serpins - Subarachnoid hemorrhage

inizio pagina