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JOURNAL OF NEUROSURGICAL SCIENCES

Rivista di Neurochirurgia


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Journal of Neurosurgical Sciences 2017 August;61(4):403-15

DOI: 10.23736/S0390-5616.16.03457-3

Copyright © 2015 EDIZIONI MINERVA MEDICA

lingua: Inglese

Surgical and endovascular treatment of poor-grade aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis

Bing ZHAO 1, Alejandro RABINSTEIN 2, Mohammad H. MURAD 3, Giuseppe LANZINO 1, Pietro PANNI 4, Waleed BRINJIKJI 5

1 Department of Neurosurgery, Mayo Clinic, Rochester, MN,USA; 2 Department of Neurology, Mayo Clinic, Rochester, MN, USA; 3 Center for Science of Healthcare Delivery, Mayo Clinic, Rochester, MN, USA; 4 San Raffaele University Hospital, Milan, Italy, 5 Department of Radiology, Mayo Clinic, Rochester, MN, USA


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INTRODUCTION: Poor-grade aneurysmal subarachnoid hemorrhage (aSAH) is associated with high morbidity and mortality. We evaluated trends in outcomes and treatment of poor-grade aSAH and performed a meta-analysis evaluating outcomes by treatment modality.
EVIDENCE ACQUISITION: We performed a literature search for studies on surgical and endovascular treatment of poor-grade aSAH. We performed a random effects meta-analysis evaluating long-term good neurological outcome, long-term poor neurological outcome and mortality, comparing rates between endovascular and surgical treatments. We performed a subgroup analysis of outcome by treatment timing relative to the aSAH separating treatment timing into three categories: 1) ultra-early (within 48 hours of aSAH); 2) early (between 48 hours-1 week post-aSAH); and 3) delayed (>1 week post-aSAH). We also evaluated trends in treatment modalities and good neurological outcome.
EVIDENCE SYNTHESIS: Eighty-five non-comparative studies with 4506 patients with poor-grade aSAH were included. The proportion of patients receiving endovascular treatment increased from 10.0% to 62.0% between 1990-2000 and 2010-2014. The rate of good neurological outcome increased from 37.0% to 44.0% over this time period. Long-term good neurological outcome was 38% (95% CI=33-43%) in the endovascular group and 39% (95% CI=34-44%) in the surgical group (P=0.74). Mortality rates were higher in the endovascular group compared to the surgical group (41% versus 31%, P=0.01). Overall, patients receiving ultra-early treatment had the highest rates of good neurological outcome (61% compared to 40% for early and 47% for delayed, P<0.01).
CONCLUSIONS: Good neurological outcome rates are similar between surgery and endovascular treatment of poor grade aSAH. Ultra-early treatment is associated with improved clinical outcomes.


KEY WORDS: Subarachnoid hemorrhage - Endovascular procedures - Surgery - Meta-analysis

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Publication History

Issue published online: May 29, 2017
Article first published online: September 9, 2015
Manuscript accepted: August 14, 2015
Manuscript received: August 9, 2015

Per citare questo articolo

Zhao B, Rabinstein A, Murad MH, Lanzino G, Panni P, Brinjikji W. Surgical and endovascular treatment of poor-grade aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. J Neurosurg Sci 2017;61:403-15. DOI: 10.23736/S0390-5616.16.03457-3

Corresponding author e-mail

bing.zhao@mayo.edu