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REVIEWS  BRAIN NEUROMODULATION SURGERY 

Journal of Neurosurgical Sciences 2016 June;60(2):211-7

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Deep brain stimulation for aggressive behavior and obsessive-compulsive disorder

Giuseppe MESSINA 1, Lucrezia ISLAM 2, Roberto CORDELLA 1, Orsola GAMBINI 2, Angelo FRANZINI 1

1 Unit of Functional Neurosurgery, Fondazione IRCCS Istituto Neurologico “Carlo Besta”, Milan, Italy; 2 Unit of Psichiatry, University of Milan Medical School, San Paolo Hospital, Milan, Italy



Drug-resistant obsessive-compulsive disorder and aggressive behavior are two severely disabling psychiatric conditions which may carry a certain burden on the patients themselves and on their families. In the last decade, the fields of interests of deep brain stimulation (DBS) also encompass psychiatric disorders, supported by imaging and neurophysiological techniques. We here report our institutional experience with the two above-mentioned disorders, describing the procedure commonly employed and the results obtained. Refinement of such techniques, possibly relying on advanced magnetic resonance imaging (MRI), together with probabilistic pictures of field of activation models, could shed more light into this complex field of investigation; further studies are necessary to confirm and make actual results a starting point to new and more precise methodologies in this stimulating research field.

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