CASE REPORTS   

Journal of Neurosurgical Sciences 2003 June;47(2):113-6

Copyright © 2004 EDIZIONI MINERVA MEDICA

lingua: Inglese

Radiation-induced schwannomas of the nervous system. Report of five cases and review of the literature

Salvati M. ¹, Polli F. M. ², Caroli E. ², Frati. A. ¹, Missori P. ², Delfini R. ²

¹ Department of Neurosurgery, IRCCS INM Neuromed, Pozzilli (Isernia), Italy 2 Division of Neurosurgery, Department of Neurological Sciences, University of Rome “La Sapienza”, Rome, Italy

Radiation ther­a­py has impor­tant ­delayed ­effects on the cen­tral ner­vous ­system. Prominent ­among ­these ­effects is radi­a­tion necro­sis of ner­vous tis­sue, but an onco­gen­ic ­effect is ­also rec­og­nized. Both ­benign and malig­nant intra­cra­ni­al ­tumors can devel­op in irra­di­at­ed ­fields, par­tic­u­lar­ly in chil­dren. Most of ­these ­tumors are sar­co­mas, menin­gio­mas or gli­o­mas and ­only occa­sion­al­ly schwan­no­mas. We ­report 5 cas­es of ­postirra­di­a­tion acous­tic ­nerve schwan­no­ma ­observed in our Department.