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Minerva Urology and Nephrology 2021 Apr 22

DOI: 10.23736/S2724-6051.21.04314-7

Copyright © 2021 EDIZIONI MINERVA MEDICA

lingua: Inglese

Improving the stratification of intermediate risk prostate cancer

Luigi NOCERA 1, 2 , Claudia COLLÀ RUVOLO 1, 3, Lara F. STOLZENBACH 1, 4, Marina DEUKER 1, 5, Zhe TIAN 1, Giorgio GANDAGLIA 2, Nicola FOSSATI 2, Firas ABDOLLAH 6, Nazareno SUARDI 7, Vincenzo MIRONE 3, Markus GRAEFEN 4, Felix K. CHUN 5, Fred SAAD 1, Francesco MONTORSI 2, Alberto BRIGANTI 2, Pierre I. KARAKIEWICZ 1

1 Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Quebec, Canada; 2 Division of Experimental Oncology/Unit of Urology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy; 3 Department of Urology, University of Naples Federico II, Naples, Italy; 4 Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany; 5 Department of Urology, University Hospital Frankfurt, Frankfurt am Main, Germany; 6 Center for Outcomes Research, Analytics, and Evaluation, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA; 7 Department of Urology, Policlinico San Martino Hospital, University of Genoa, Genoa, Italy



BACKGROUND: Intermediate risk prostate cancer (IR PCa) may exhibit a wide array of phenotypes, from favorable to unfavorable. NCCN criteria help distinguishing between favorable versus unfavorable subgroups. We studied and attempted to improve this classification.
METHODS: Within the SEER database 2010-2016, we identified 19,193 IR PCa patients treated with radical prostatectomy. A multivariable logistic regression model predicting unfavorable IR PCa was developed and externally validated, in addition to a head-to-head comparison with NCCN IR PCa stratification.
RESULTS: Model development (development cohort n=13,436: 3,585 unfavorable versus 9,851 favorable) rested on age, PSA, clinical T stage, biopsy Gleason Grade Group (GGG) and percentage of positive cores. All were independent predictors of unfavorable IR PCa. In external validation cohort (n=5,757: 1,652 unfavorable versus 4,105 favorable), NCCN stratification was 61.8% accurate in discriminating between favorable versus unfavorable, compared to 67.6% for nomogram, which exhibited excellent calibration, less pronounced departures from ideal prediction and greater net-benefit in decision curve analyses (DCA) than NCCN stratification. The optimal nomogram cutoff misclassified 312 of 1976 patients (15.8%) versus 598 of 2877 (20.8%) for NCCN stratification. Of NCCN misclassified patients, 90.0% harbored pT3-4 stages versus 84.6% of nomogram.
CONCLUSIONS: The newly developed, externally validated nomogram discriminates better between favorable versus unfavorable IR PCa, according to overall accuracy, calibration, DCA, and actual numbers and stage distribution of misclassified patients.


KEY WORDS: IR; Prostate cancer; PCa; Nomogram; SEER; Favorable; Unfavorable; AS; Active surveillance

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