ORIGINAL ARTICLE   Free access

Minerva Urologica e Nefrologica 2020 December;72(6):763-9

DOI: 10.23736/S0393-2249.20.03551-1

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

En-bloc resection of bladder tumors for pathological staging: the value of lateral margins analysis

Ahmed EISSA ^{1, 2}, Ahmed ZOEIR ^{1, 2}, Silvia CIARLARIELLO ¹, Luca SARCHI ¹, Maria C. SIGHINOLFI ¹, Ahmed GHAITH ², Stefano PULIATTI ¹, Raffaele INZILLO ¹, Luca REGGIANI BONETTI ³, Mino RIZZO ¹, Bernardo ROCCO ¹, Salvatore MICALI ¹ ✉

¹ Department of Urology, University of Modena and Reggio Emilia, Modena, Italy; ² Department of Urology, Faculty of Medicine, Tanta University, Tanta, Egypt; ³ Section of Pathology, Department of Diagnostic Medicine and Public Health, University of Modena and Reggio Emilia, Modena, Italy

BACKGROUND: In endoscopic resection of colorectal tumors, the pathological assessment of the lateral margins is a strong predictor of tumor recurrence after resection. The aim of the current study is to evaluate the value of the peritumoral margins assessment in ERBT on tumor recurrence.
METHODS: We retrospectively analyzed the data of 50 consecutive patients with NMIBC and treated by ERBT between January and December 2017.
RESULTS: The lateral margins showed dysplasia in 16 patients and malignancy in three patients. Local recurrence occurred in 14 (28%) patients. It was noted that 57% of patients with recurrence showed some degree of dysplasia or malignancy in the lateral margin; however, on multivariate logistic regression lateral margins lesions were not significantly associated with recurrence (OR 2.175, 95% CI: 0.430-10.996, P=0.35).
CONCLUSIONS: ERBT may improve the pathological report of bladder tumor. There was a trend toward increased rate of recurrence in patients with dysplasia or malignancy in their lateral margins; however, this was not statistically significant on multivariate analysis. Further studies with larger sample sizes are required to assess the value of lateral margin analysis.

KEY WORDS: Urinary bladder neoplasms; Colorectal neoplasms; Margins of excision; Local neoplasm recurrence