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Minerva Urologica e Nefrologica 2020 December;72(6):763-9

DOI: 10.23736/S0393-2249.20.03551-1

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

En-bloc resection of bladder tumors for pathological staging: the value of lateral margins analysis

Ahmed EISSA 1, 2, Ahmed ZOEIR 1, 2, Silvia CIARLARIELLO 1, Luca SARCHI 1, Maria C. SIGHINOLFI 1, Ahmed GHAITH 2, Stefano PULIATTI 1, Raffaele INZILLO 1, Luca REGGIANI BONETTI 3, Mino RIZZO 1, Bernardo ROCCO 1, Salvatore MICALI 1

1 Department of Urology, University of Modena and Reggio Emilia, Modena, Italy; 2 Department of Urology, Faculty of Medicine, Tanta University, Tanta, Egypt; 3 Section of Pathology, Department of Diagnostic Medicine and Public Health, University of Modena and Reggio Emilia, Modena, Italy



BACKGROUND: In endoscopic resection of colorectal tumors, the pathological assessment of the lateral margins is a strong predictor of tumor recurrence after resection. The aim of the current study is to evaluate the value of the peritumoral margins assessment in ERBT on tumor recurrence.
METHODS: We retrospectively analyzed the data of 50 consecutive patients with NMIBC and treated by ERBT between January and December 2017.
RESULTS: The lateral margins showed dysplasia in 16 patients and malignancy in three patients. Local recurrence occurred in 14 (28%) patients. It was noted that 57% of patients with recurrence showed some degree of dysplasia or malignancy in the lateral margin; however, on multivariate logistic regression lateral margins lesions were not significantly associated with recurrence (OR 2.175, 95% CI: 0.430-10.996, P=0.35).
CONCLUSIONS: ERBT may improve the pathological report of bladder tumor. There was a trend toward increased rate of recurrence in patients with dysplasia or malignancy in their lateral margins; however, this was not statistically significant on multivariate analysis. Further studies with larger sample sizes are required to assess the value of lateral margin analysis.


KEY WORDS: Urinary bladder neoplasms; Colorectal neoplasms; Margins of excision; Local neoplasm recurrence

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