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Minerva Urologica e Nefrologica 2018 February;70(1):95-101

DOI: 10.23736/S0393-2249.17.02869-7

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Clinical observation of umbilical cord mesenchymal stem cell transplantation for treating patients receiving peritoneal dialysis

Hong-Ying JIANG 1, Jia-Ping WANG 2, Yi-Hua BAI 1 , Min YANG 1, Yi ZENG 1, Yun-Juan LIAO 1, Zhen-Kun HE 1

1 Department of Nephrology, the Second Hospital Affiliated Kunming Medical University, Kunming, China; 2 Department of Radiology, the Second Affiliated Hospital of Kunming Medical University, Kunming, China


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BACKGROUND: This study aims to observe the outcome and safety of umbilical cord-mesenchymal stem cell (UC-MSC) treatment for continuous ambulatory peritoneal dialysis (CAPD) patients.
METHODS: A total of 24 CAPD patients, who underwent UC-MSC treatment from June 2011 to December 2012, were selected for this study. These patients were followed up until June 2015.
RESULTS: Results revealed a significant increase in hemoglobin, erythropoietin and albumin levels, a decrease in C-reactive protein levels, and marked improvement in cystatin C and urine volume within three months after UC-MSC transplantation; and the difference was statistically significant (P<0.05). However, the difference in residual glomerular filtration rate, serum creatinine, peritoneal KT/V and remnant kidney KT/V was not statistically significant (P>0.05).
CONCLUSIONS: Clinical indicators of patients with CAPD can be partially improved through UC-MSC treatment.


KEY WORDS: Umbilical cord - Mesenchymal stromal cells - Peritoneal dialysis - Therapy - C-reactive protein - Erythropoietin

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Publication History

Issue published online: January 30, 2018
Article first published online: September 7, 2017
Manuscript accepted: September 4, 2017
Manuscript revised: May 9, 2017
Manuscript received: November 29, 2016

Per citare questo articolo

Jiang HY, Wang JP, Bai YH, Yang M, Zeng Y, Liao YJ, et al. Clinical observation of umbilical cord mesenchymal stem cell transplantation for treating patients receiving peritoneal dialysis. Minerva Urol Nefrol 2018;70:95-101. DOI: 10.23736/S0393-2249.17.02869-7

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byhkofrssvnjb@163.com