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MINERVA UROLOGICA E NEFROLOGICA

Rivista di Nefrologia e Urologia


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Minerva Urologica e Nefrologica 2018 February;70(1):79-86

DOI: 10.23736/S0393-2249.17.02887-9

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Expression of GFRα3 correlates with tumor progression and promotes cell metastasis in urothelial carcinoma

Yang YAN, Meng-Nan LI, Bin YANG, Jiang GENG, Jun-Hua ZHENG, Xu-Dong YAO

Department of Urology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China


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BACKGROUND: Urothelial carcinoma (UC) is a major health problem in the general population. We aimed to evaluate the function of GFRα3 and unravel its underlying molecular mechanism to develop novel treatment options equivalent to UC.
METHODS: To evaluate the function of GFRα3, a group of 60 pairs of UC patients were recruited in for this study. UC tissues and their adjacent normal control tissues (NCTs) were collected between 2012 and 2015. We used immunohistochemistry to analyze the correlation between GFRα3 expression and clinicopathologic variables and patient survival. The role of regulation of GFRα3 in UC was applied in vitro. In addition, we further investigated the signaling pathway of GFRα3 in UC progression.
RESULTS: The expression level of GFRα3 was remarkably upregulated in 49.3% (19/60) patients and downregulated in 25.0% (15/60) patients. The GFRα3 protein expression was upregulated in UC tissues. GFRα3 promotes UC cell migration and invasion in vitro. GFRα3 also promotes UC cell metastasis in vitro. High level of GFRα3 promotes UC cell migration via upregulation of MMP9 expression.
CONCLUSIONS: Our results demonstrate that increased GFRα3 expression is significantly correlated with poor prognosis of patients with UC. Thus, GFRα3 might be an important marker and a therapeutic target for UC.


KEY WORDS: Human GFRA3 protein - Transitional cell carcinoma - Disease progression - Neoplasm metastasis

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Publication History

Issue published online: January 30, 2018
Article first published online: June 23, 2017
Manuscript accepted: May 22, 2017
Manuscript revised: March 29, 2017
Manuscript received: January 2, 2017

Per citare questo articolo

Yan Y, Li MN, Yang B, Geng J, Zheng JH, Yao XD. Expression of GFRα3 correlates with tumor progression and promotes cell metastasis in urothelial carcinoma. Minerva Urol Nefrol 2018;70:79-86. DOI: 10.23736/S0393-2249.17.02887-9

Corresponding author e-mail

drxudong_yao@126.com