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Minerva Urologica e Nefrologica 2017 October;69(5):509-18

DOI: 10.23736/S0393-2249.17.02830-2

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Prevalence of chronic prostatic inflammation based on clinical diagnostic criteria in a real-practice setting: a nation-wide observational study

Ferdinando FUSCO 1, Davide ARCANIOLO 2 , Anna RESTAINO 3, 4, Irene LAURI 5, Corrado FRANZESE 3, on behalf of the SIUT Prostatic Inflammation Study Group 

1 Federico II University, Naples, Italy; 2 University of Campania "L. Vanvitelli", Naples, Italy; 3 SIUT, Nola, Italy; 4 Camadoli Clinic, Naples, Italy; 5 Private Practitioner, Frosinone, Italy


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BACKGROUND: Chronic prostatic inflammation has a key role in the pathogenesis and progression of benign prostatic hyperplasia (BPH). Thus, the identification of patients with chronic inflammation is mandatory for Urologists. This study investigates which clinical, imaging and laboratory findings are used by Urologists in clinical practice to diagnose BPH and chronic prostate inflammation.
METHODS: This was a multicenter, non-interventional, observational study involving 30 Italian large-volume primary care urology centers. Patients were allocated into four diagnosis group: patients with BPH; patients with BPH and chronic prostate inflammation; patients with chronic prostate inflammation alone; and patients with lower urinary tract symptoms (LUTS) due to other causes.
RESULTS: In total, 6134 patients were enrolled. BPH diagnosis with or without concomitant prostate inflammation was more frequent in older patients, while inflammation alone was prevalent in younger patients. Predictive factors for diagnosis of inflammation in all patients, regardless of age, were normal urinary flow (OR=2.73) and proved in-fection (OR=5.90), while in older patients (>61 years) diagnosis of chronic prostatic inflammation was specifically predicted by higher PSA values (≥4 ng/mL; OR=2.91), normal prostate volume (OR=10.23), mild symptoms (IPSS <8; OR=1.84), presence of intraprostatic calcifications (OR=4.55), and the combination of both infection and calcifications (OR=10.79).
CONCLUSIONS: In daily practice, the presence of chronic prostatic inflammation is underestimated. A stricter application of established diagnostic criteria suggested would increase the detection rate of chronic prostatic inflammation and potentially change the therapeutic approach in many patients with LUTS.


KEY WORDS: Prostatic hyperplasia - Clinical protocols - Diagnosis - Inflammation

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Publication History

Issue published online: July 21, 2017
Article first published online: January 24, 2017
Manuscript accepted: January 10, 2017
Manuscript revised: December 13, 2016
Manuscript received: October 7, 2016

Per citare questo articolo

Fusco F, Arcaniolo D, Restaino A, Lauri I, Franzese C; SIUT Prostatic Inflammation Study Group. Prevalence of chronic prostatic inflammation based on clinical diagnostic criteria in a real-practice setting: a nation-wide observational study. Minerva Urol Nefrol 2017;69:509-18. DOI: 10.23736/S0393-2249.17.02830-2

the SIUT Prostatic Inflammation Study Group

Davide ARCANIOLO, Rosanna ALEI, Sara BAIETTO, Roberto BRIGATO, Giovanni CARETTO, Stefania CHIERCHIA, Bianca M. CIAMMARUGHI, Francesco COMERCI, Francesco COTO, Nunzio D’ARMA, Claudia DE MARIA, Giuseppe DI CROSTA, Giuseppe DI GIOVACCHINO, Carmelo FALLETTA, Francesco FARINA, Fusco FERDINANDO, Corrado FRANZESE, Raffaele GAMBARDELLA, Giuseppe GAROFANO, Marcello CURTI GIARDINA, Pasquale GRELLA, Irene LAURI, Fedele LASAPONARA, Giovanni LOMBARDI, Luciana MARIANI, Vincenzo MARINO, Vincenzo MILIOTO, Gianfranco MOSELE, Stefano PANGRAZI, Claudio PLANTULLI, Libertario RAFFAELLI, Giuliano RAVA, Gaetano RESSA, Anna RESTAINO, Francesco SEMINARA, Manuel A. VALENTINI, Viviana VERONESE

Corresponding author e-mail

Davide_arcaniolo@yahoo.it