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Minerva Surgery 2022 Feb 17

DOI: 10.23736/S2724-5691.22.09369-8

Copyright © 2022 EDIZIONI MINERVA MEDICA

lingua: Inglese

Complications after bowel resection for inflammatory bowel disease associated cancer. A systematic literature review

Monica ORTENZI 1, Andrea BALLA 2 , Giovanni LEZOCHE 1, Sara COLOZZI 1, Roberto VERGARI 1, Diletta CORALLINO 3, Livia PALMIERI 3, Francesca MEOLI 3, Alessandro M. PAGANINI 3, Mario GUERRIERI 1

1 Department of General and Emergency Surgery, Marche Polytechnic University, Ancona, Italy; 2 Unit of General and Minimally Invasive Surgery, San Paolo Hospital, Civitavecchia, Rome, Italy; 3 Paride Stefanini Department of General Surgery and Surgical Specialties, Sapienza University, Rome, Italy


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INTRODUCTION: Inflammatory bowel disease (IBD) associated colorectal cancer represents the 1-2% of all patients affected by colorectal carcinoma, but it is frequent responsible for death in these patients. Aim of this systematic review was to report the complications after bowel resection in patients with IBD associated cancer.
EVIDENCE ACQUISITION: A systematic review was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis statement. The search was carried out in PubMed, Embase, Cochrane and Web of Science databases. A total of 54,084 articles were found. Of these 38,954 were eliminated because were duplicates between the searches. Of the remaining 15,130 articles, 14,888 were excluded after screening title and abstract.
EVIDENCE SYNTHESIS: Two-hundred-forty-two articles were fully analyzed, and 239 further articles were excluded. Finally, three articles were included for a total of 63 patients. Overall, 38 early postoperative complications (60.3%) were observed. Of these, anastomotic leakage occurred in 13 patients (20.6%). The indication for surgery was ulcerative colitis in 52 patients (82.5%), Crohn’s disease in 8 patients (12.7%) and indeterminate colitis in 3 patients (4.8%). Intraoperative complications, readmission and postoperative mortality were not observed.
CONCLUSIONS: Complication rate after bowel resection for IBD associated cancer is not different from complication rate after colorectal surgery for other diseases. Given the high probability of developing a cancer and the time correlated occurrence of malignancy in IBD patients, it should be debated if a surgical resection should be performed as soon as dysplasia is detected in IBD patients or earlier in their life.


KEY WORDS: Inflammatory bowel diseases; Colitis, ulcerative; Crohn disease; Neoplasms; Complications

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