ARTICOLI ORIGINALI   

Minerva Chirurgica 2015 June;70(3):175-80

Copyright © 2015 EDIZIONI MINERVA MEDICA

lingua: Inglese

Role of TachoSil® in distal pancreatectomy: a single center experience

Silvestri S. ¹, Franchello A. ¹, Gonella F. ¹, Deiro G. ¹, Campra D. ¹, Cassine D. ¹, Fiore A. ¹, Ostuni E. ¹, Garino M. ², Resegotti A. ¹, Farina E. C. ¹, Fronda G. R. ¹ ✉

¹ 4th General Surgery Department, A.O.U. Città della Salute e della Scienza, Turin, Italy; ² Department of General Surgery, A.O. Ospedale di Rivoli, Rivoli, Turin, Italy

AIM: Distal pancreatectomies (DP) are associated with high risk of postoperative complications, and in many series higher morbidity rate than duodenopancreatectomies has been reported. To evaluate the role of a collagen sponge with human fibrinogen and thrombin film (TachoSil®) in limiting the incidence of complications after DP.
METHODS: From 1996 to 2013, 221 patients have been submitted to distal pancreatectomy (+/- splenectomy) in our Division. A retrospective analysis has been conducted in a group of 36 consecutive and prospectively collected DP treated with intraoperative placement of TachoSil® on pancreatic stump from 2010 to 2013 (group 1). A control series of 36 consecutive patients (group 2) was matched 1:1 from hystorical database. The variables considered in the analysis were: age, gender, ASA score, pancreatic texture (hard vs. soft), histology, operative time, postoperative mortality, morbility (postoperative pancreatic fistula - POPF, postoperative hemorrage - PPH, delayed gastric emptying - DGE) and hospital stay. Differences between POPF, PPH, DGE and hospital stays between grops were investigated with χ2 and t-Student test. Univariate analysis was conducted to determine factors related to POPF development. Statistical analysis was performed using freeware Microsoft Excel based program.
RESULTS: Post operative mortality was 0% in both groups. POPF were registered in 36.1% (13/36) and 41.6 % (15/36) in groups 1 and 2, respectively (P=n.s.); in group 1 we didn’t observe grade C POPF, while 4 patients in control group developed grade C POPF (P<0,05). No differences were found between two groups in terms of incidence of PPH and DGE. The median duration of postoperative hospital stay in group 1 was 21.8 (7-189) days compared with 31.13 (9-249) days in group 2 (P<0.001).
CONCLUSION:The use of TachoSil® seems to be associated with lower incidence of grade C POPF but larger controlled trials are needed to surely assess the usefulness of TachoSil® in pancreatic surgery in order to reduce pancreatic specific complications and their severity.