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Minerva Stomatologica 2020 June;69(3):127-32

DOI: 10.23736/S0026-4970.20.04269-7

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Expression of mast cell in aggressive periodontitis

Maryam SHAHSAVARI 1, Siavash AZIZI MAZREAH 2, Parvin ARBABI KALATI 3

1 Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, Zahedan University of Medical Sciences, Zahedan, Iran; 2 School of Dentistry, Zahedan University of Medical Science, Zahedan, Iran; 3 Department of Periodontology, Zahedan University of Medical Sciences, Zahedan, Iran



BACKGROUND: Aggressive periodontitis is a progressive disease that can cause tooth loss within a short period of time. Mast cells are found in tissues with various allergic and inflammatory conditions including periodontal disease through the release of cytokines, chemokines, and proteolytic enzymes. Given the findings of some studies on the related role of mast cells, this study was conducted to determine the number of mast cells in aggressive periodontitis.
METHODS: This study was conducted on 30 participants divided into two groups visiting the Faculty of Dentistry of University of Medical Sciences. A total of 15 participants with aggressive periodontitis and 15 healthy participants were investigated. For counting mast cells, toluidine blue staining was used. The percentage of mast cells and demographic factors were evaluated in the two groups and the results were analyzed in SPSS using descriptive statistics and independent t-tests. A P value <0.05 was considered significant.
RESULTS: The mean percentage of mast cells in the aggressive periodontitis group was 27.1±8.9 which was significantly higher than that of the healthy group, i.e. 12.6±5.1 (P<0.001).
CONCLUSIONS: In general, the results of the study showed that the percentage of mast cells in the aggressive periodontitis group was more than two times higher than that of the healthy group, which is indicative of an increase in the number of mast cells in aggressive periodontitis disease.


KEY WORDS: Mast cells; Aggressive periodontitis, Tolonium chloride

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