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Rivista di Odontostomatologia e Chirurgia Maxillo-Facciale

Official Journal of the Italian Society of Odontostomatology and Maxillofacial Surgery
Indexed/Abstracted in: CAB, EMBASE, Index to Dental Literature, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index




Minerva Stomatologica 2018 February;67(1):1-11

DOI: 10.23736/S0026-4970.17.04084-5


lingua: Inglese

Adjunctive use of an ethyl lauroyl arginate-(LAE-)-containing mouthwash in the nonsurgical therapy of periodontitis: a randomized clinical trial

Andrea PILLONI 1, Mauro CARERE 1, Germano ORRÙ 2, Alessandra SCANO 2, Cinzia TREZZA 1, Mariana A. ROJAS 3, Blerina ZEZA 1

1 Section of Periodontics, Department of Dentistry and Maxillofacial Surgery, Sapienza University, Rome, Italy; 2 Department of Surgical Science, University of Cagliari, Cagliari, Italy; 3 Department of Periodontics, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina


BACKGROUND: This randomized clinical trial evaluated the clinical and microbiological effects of 0.147% ethyl lauroyl arginate (LAE)-containing mouthwash compared to 0.12% chlorhexidine (CHX) mouthwash in the treatment of periodontitis.
METHODS: Subjects were randomized to use 0.147% LAE and 0.12% CHX mouthwash after professional mechanical plaque removal (PMPR) twice daily 1 hour after brushing for 4 weeks. Periodontal pocket depth (PPD), bleeding on probing (FMBS) and dental plaque (FMPS) were measured at baseline, 4 weeks and 3 months. Microbiological samples were taken at baseline, at 4 weeks and 3 months after plaque recording and prior to PPD and BoP measurements.
RESULTS: Forty subjects were randomized to treatment. Both therapies resulted in reduced FMPS, FMBS and residual pockets at 4 weeks and 3 months. The differences were not statistically significant. There were no treatment-related adverse events. Total bacterial count and the specific pathogens were reduced at 4 weeks and 3 months by both mouthwashes with no statistical differences between them at neither period of time.
CONCLUSIONS: A mouthwash containing 0.147% LAE could be an alternative to the use of 0.12% CHX in the non-surgical therapy of periodontitis considering the similar clinical effects, more stable microbiological improvement and absence of adverse effects.

KEY WORDS: Periodontal index - Chlorhexidine - N(alpha)-lauroylarginine ethyl ester - Mouthwashes - Periodontal diseases

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Publication History

Issue published online: December 7, 2017
Article first published online: October 31, 2017
Manuscript accepted: October 25, 2017
Manuscript revised: October 6, 2017
Manuscript received: May 16, 2017

Per citare questo articolo

Pilloni A, Carere M, Orrù G, Scano A, Trezza C, Rojas MA, et al. Adjunctive use of an ethyl lauroyl arginate-(LAE-)-containing mouthwash in the nonsurgical therapy of periodontitis: a randomized clinical trial. Minerva Stomatol 2018;67:1-11. DOI: 10.23736/S0026-4970.17.04084-5

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