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Minerva Stomatologica 2014 July-August;63(7-8):273-81

Copyright © 2014 EDIZIONI MINERVA MEDICA

lingua: Inglese

Adipose derived stem cells: basic science fundaments and clinical application. An update

Lauritano D. 1, Palmieri A. 2, Vinci R. 3, Azzi L. 4, Tagliabue A. 4, Carinci F. 5

1 Department of Interdisciplinary Surgery and Medicine, University Milano Bicocca, Milan, Italy; 2 Department of Experimental Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; 3 University Vita e Salute, San Raffaele Hospital, Milan, Italy; 4 University of Insubria, Dental Clinic, Varese, Italy; 5 Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy


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Soft tissues regeneration can be used to treat several kinds of diseases including congenital and post traumatic deformities, and to fill out tissue depression due to orbital and periorbital surgery, scars or cancer resections. Generally it is performed by the use of autologous tissue flaps, alloplastic implants and autologous fat grafting. All of these methods have several disadvantages, which include resorption of the autologous material, foreign body reaction and implant migration. Stem cell application has been suggested as a possible novel therapy for regenerative medicine thanks to their unlimited capacity of self-renewal, as well as the property to differentiate into multiple cell types under appropriate stimuli. This short review describe the recent development in stem cells isolation, expansion and characterization and their employment in tissue regeneration and tissue engineering.

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