ORIGINAL ARTICLE   

Minerva Pneumologica 2018 December;57(4):85-91

DOI: 10.23736/S0026-4954.18.01831-X

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

The relationship of vitamin D level with markers of cardiorenal syndrome in patients with chronic obstructive pulmonary disease

Elena BOLOTOVA ¹, Valeriya YAVLYANSKAYA ^{1, 2} ✉, Anna DUDNIKOVA ^{1, 2}

¹ Department of Postgraduate Training “Therapy1”, Kuban State Medical University, Krasnodar, Russia; ² Regional Clinical Hospital 2 of the City of Krasnodar, Krasnodar, Russia

BACKGROUND: The goal was to study the relationship of vitamin D levels with markers of cardiorenal syndrome in patients with chronic obstructive pulmonary disease (COPD) depending on the severity of bronchial obstruction.
METHODS: The study included 198 patients with COPD divided into 2 groups depending on the severity of bronchial obstruction: (group 1 - FEV1≥50% (1-2 GOLD severity stage) - 90 patients, group 2 with FEV1<50% (3-4 GOLD severity stage)-108 patients). In all patients the levels of cardiorenal syndrome markers, such as cystatin C, urea, uric acid, C-reactive protein (CRP), albuminuria with the calculation of albumin-creatinine ratio, blood electrolytes (total and ionized calcium, inorganic phosphorus), calculated the Smoking index, vitamin D by high-performance liquid chromatography were assessed.
RESULTS: In COPD patients a positive correlation between vitamin D levels and the severity of bronchial obstruction (r=0.419, P=0.001) and negative correlation between vitamin D and frequency of COPD exacerbations (r=-0.421, P=0.005) and CRP (r=-0.301, P=0.029) were observed. There was a significant correlation between the level of vitamin D and albumin/creatinine ratio (r=-0.345, P=0.021). A lower frequency of hyperphosphatemia was found in group 2 (63.16% vs. 78.69%, χ2=6.627, P=0.032), a positive correlation between serum phosphorus level and vitamin D level (r=0.475, P=0.025) was also found.
CONCLUSIONS: The level of vitamin D, in a number of clinical situations, can be considered as a promising biomarker of the cardiorenal continuum state in patients with COPD. Its correction is a possible way to slow the progression of cardiovascular complications in patients with COPD.

KEY WORDS: Vitamin D - Cardio-renal syndrome - Pulmonary disease, chronic obstructive