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Minerva Pneumologica 2015 December;54(4):161-8


lingua: Inglese

Epidemiology, clinical profiles and risk factors in obstructive sleep apnea

Uzma N. 1, Hasan A. 2, Kumar B. S. 3, Qaiyum H. A. 4, Basalingappa D. R. 5, Reddy D. 6

1 Department of Physiology, Deccan College of Medical Sciences, Hyderabad, India; 2 Department of Respiratory Medicine, Owaisi Hospital and Research Center, Hyderabad, India; 3 Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India; 4 Department of ENT, Deccan College of Medical Sciences, Hyderabad, India; 5 Department of Physiology, Kameneni Institute of Medical Sciences, Narketpally, Nalgonda; 6 Department of Physiology, Anna Medical College and Research Centre, Mauritius, India


Obstructive sleep apnea (OSA) is a common medical condition with significant adverse effects but it remains undiagnosed in many individuals. The present hospital based study assessed the prevalence, related clinical features and risk factors of OSA in the South Indian population. One ninety two untreated OSA patients and sixty two control subjects were included in this study. Each subject underwent a fully attended polysomnogram (PSG), spirometric analysis, modified OSA questionnaires and Mallampati score were obtained in study population. The OSA patients were divided into three subgroups: mild (29%), moderate (15%) and severe (56%) and the mean±SD of Apnea-Hypopnea Index (AHI) was 11.4±3, 24.8±5.1 and 36.6±7.4 respectively. Higher Mallampati score was observed in patients with severe OSA than in moderate and mild OSA patients. An apparent decrease in FVC and FEV1 was observed in OSA group with a positive correlation with increase in AHI. A significant decrease in FVC, FEV1 and FEV1/FVC was observed with increase in Body Mass Index (BMI), reflecting the increased restrictive pattern in the OSA groups. Sleep onset latency was increased to 18.6±13.2 than 8.8±3.2 with a sleep efficiency of 74.2±4.8 and 90.2% in OSA group and controls respectively. The apnea index, hypopnea index and microarousals were much higher in the OSA groups than in controls. Statistically significant differences were perceived in the fasting blood glucose levels, triglyceride, LDL, HDL and total cholesterol levels between the OSA group and controls. This study adds evidence for a link between the clinical features, epidemiology and risk factors of OSA.

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