Home > Riviste > Minerva Pediatrics > Fascicoli precedenti > Articles online first > Minerva Pediatrics 2021 Apr 16

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo
Share

 

 

Minerva Pediatrics 2021 Apr 16

DOI: 10.23736/S2724-5276.21.06221-6

Copyright © 2021 EDIZIONI MINERVA MEDICA

lingua: Inglese

Effects of soy-containing infant formulas on thyroid gland in rats

Serdar ÇULCU 1 , Ebrar AKKAYA 2, Erhan AYSAN 3, Mirkhalig JAVADOV 3, Alev CUMBUL 4

1 Faculty of Medicine, A.Y. Ankara Onkology Hospital, University of Health Science, Ankara, Turkey; 2 Faculty of Medicine Student, Bezmialem Vakif University, Istanbul, Turkey; 3 Department of General Surgery, Faculty of Medicine, Yeditepe University, Istanbul, Turkey; 4 Department of Histology and Embriology, Faculty of Medicine, Yeditepe University, Istanbul Turkey


PDF


BACKGROUND: Effects of soy-containing infant formulas on the thyroid gland is not clear. We aimed to evaluate the effects of infant formulas with different quantities of soy content on the functional and histopathological characteristics of the thyroid gland.
METHODS: Twenty-eight female Sprague-Dawley rats were divided into four groups. Group 1 was fed with standard pellet rat food (8g/day); Group 2 soy-free infant formula (8g/day); Group 3 low-dose (1.12g/100ml) soy-containing formula (8g/day), and Group 4 high-dose (2.64g/100ml) soy-containing formula (8g/day). Blood samples were collected from the subjects on day 0, 30, 60, and 90 to evaluate thyroid functions. All subjects were sacrificed on day 90. Thyroid glands were excised and examined histopathologically.
RESULTS: Serum levels of free T3, free T4, TSH, anti TPO, and anti TG were significantly higher in Group 4 compared to other groups (p<0.001, p<0.01,p<0.001,p=0.002). No differences were found in the histopathological findings between the groups.
CONCLUSIONS: Infant formulas with high soy content induce hyperthyroidism with high TSH levels. High levels of anti TPO and anti TG suggest that observed changes might have occurred via inflammatory mechanism.


KEY WORDS: Soy food; Thyroid; Infant formulas

inizio pagina