Home > Riviste > Minerva Pediatrics > Fascicoli precedenti > Articles online first > Minerva Pediatrica 2019 May 27



Opzioni di pubblicazione
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca


Publication history
Per citare questo articolo



Minerva Pediatrica 2019 May 27

DOI: 10.23736/S0026-4946.19.05459-8


lingua: Inglese

Left atrial subclinical dysfunction in children with Kawasaki disease: a two-dimensional speckle tracking echocardiograpy study

Haiyong WANG 1, Litao RUAN 1 , Jing SHANG 1, Yan SONG 1, Minghui TONG 2, Tingting WU 2

1 The Department of Ultrasound Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Shanxi Province, China; 2 The Third Department of Ultrasound Medicine, The Second Affiliated Hospital, Lanzhou University, Gansu Province, China


BACKGROUND: Left atrial (LA) function is a very important prognostic indicator for many cardiovascular diseases. In this study, we aimed to determine whether LA function is impaired in children with Kawasaki disease (KD) and to analyse the relationships between LA deformation and conventional echocardiographic parameters and laboratory markers.
METHODS: A total of 50 KD patients during different disease phases and 50 age- and sex- matched controls were retrospectively analysed. Patients in the acute phase based on coronary artery dilation (CAD) were subdivided into Group I (with CAD) and Group II (without CAD) and compared.
RESULTS: During the acute phase, KD patients had a lower peak LA longitudinal strain (PLALS), a lower LA strain peak during LA contraction (LASct), and a lower LA strain rate peak during LA contraction (LASRct) than the controls. The PLALS, LASct and LASRct began to increase during the subacute phase, and during the convalescent phase, all LA strains in patients had recovered to normal compared with the control subjects. Subgroup analysis revealed that, compared with Group II, Group I had higher C-reactive protein (CRP) and serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels; however, there were no significant differences in LA strains. Only the PLALS during the acute phase was negatively correlated with left ventricular mass index, CRP and NT-proBNP.
CONCLUSIONS: In patients with KD, LA function is impaired during the acute phase, and this impairment is transient. Two-dimensional speckled tracking echocardiography is a useful tool for detecting subclinical LA dysfunction.

KEY WORDS: Kawasaki disease - Left atrial function - Strain - Strain rate

inizio pagina