ORIGINAL ARTICLE   

Minerva Pediatrics 2021 June;73(3):209-14

DOI: 10.23736/S2724-5276.20.05710-2

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Direct drug provocation test for the diagnosis of self-reported, mild and immediate drug hypersensitivity reaction in children and adolescents: our real-life experience

Daniela NISTICÒ ¹, Stefano PASSANISI ² ✉, Erminia M. OPPEDISANO ², Lucia CAMINITI ², Alessandra MARINO ², Paolo RUGGERI ³, Giuseppe CRISAFULLI ², Giovanni B. PAJNO ²

¹ Department of Pediatric, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy; ² Gaetano Barresi Department of Human Pathology in Adult and Developmental Age, University of Messina, Messina, Italy; ³ Unit of Pneumology, Department of Biomedical, Dental and Morphological and Functional Images, University of Messina, Messina, Italy

BACKGROUND: Approximately 10% of the parents report suspected drug hypersensitivity reactions to at least one drug in their children, but most of these reactions are not confirmed after an adequate diagnostic work-up. The diagnosis of drugs hypersensitivity is frequently laborious and based on anamnesis, skin tests, serum specific IgE research and drug provocation test. Nevertheless, drug provocation test is necessary to confirm or definitively exclude the diagnosis of allergy. Aims of our study were to evaluate the real incidence of drug hypersensitivity in a large pediatric population and the validity of a short diagnostic algorithm.
METHODS: One hundred nine patients with a history of self-reported, immediate and mild drug hypersensitivity reactions to β-lactam antibiotics, macrolides and non-steroidal anti-inflammatory drugs underwent drug provocation test without prior skin or blood tests. After one-year, a telephone questionnaire was conducted in order to evaluate patient’s use of the tested drug and any reactions.
RESULTS: Only 7 of the 109 patients (6.4%) resulted positive to drug provocation test. No severe reactions were reported. After the challenge, 64 patients took the culprit drug again within one year and only two reported a drug reaction.
CONCLUSIONS: Drug hypersensitivity is highly overestimated. Our results prompt the opportunity to directly perform the challenge for those children with self-reported, mild and immediate drug hypersensitivity reaction.

KEY WORDS: Anti-inflammatory agents, non-steroidal; Beta-lactams; Drug hypersensitivity; Pediatrics