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ORIGINAL ARTICLE   

Minerva Pediatrics 2021 February;73(1):20-5

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Beneficial therapeutic effects of vitamin C on recurrent respiratory tract infections in children: preliminary data

Pietro FERRARA 1, 2 , Francesca IANNIELLO 1, Virginia BIANCHI 3, Fabio QUINTARELLI 2, Michela CAMMERATA 2, Enrica QUATTROCCHI 2, Gloria M. TERRANOVA 2, Giacinto A. MIGGIANO 4, Manuele CASALE 5

1 Institute of Pediatrics, Sacred Heart Catholic University, Rome, Italy; 2 Unit of Pediatrics, Campus Bio-Medico University, Rome, Italy; 3 Unit of Food Sciences and Human Nutrition, Campus Bio-Medico University, Rome, Italy; 4 Unit of Clinical Nutrition, Sacred Heart Catholic University, Rome, Italy; 5 Unit of Otolaryngology, Campus Bio-Medico University, Rome, Italy


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BACKGROUND: The aim of this study was to demonstrate whether supplementation of vitamin C has a beneficial effect in the prevention of recurrent respiratory tract infections (RTIs) in children. Moreover, we evaluate the main risk factors that predispose to the development of this disease.
METHODS: Sixty children have been enrolled in the study and randomized into two groups: the control group (G1 N.=33) and the group at risk of recurrent RTIs (G2 N.=27). To G2 group was administered every day 100% orange juice with the content of vitamin C 70 mg.
RESULTS: Significant reduction in the incidence rate of RTIs (episodes pre-treatment: 182-6.75 episodes/child, after-treatment: 71-2.62 episodes/child, P<0.05), were observed in G2 group.
CONCLUSIONS: The administration of vitamin C had a beneficial effect in our group of children with recurrent RTIs, reducing the number of infective episodes.


KEY WORDS: Ascorbic acid; Respiratory tract infections; Child

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