REVIEW  NOVEL INSIGHTS INTO PEDIATRIC ALLERGY AND IMMUNOLOGY Free

Minerva Pediatrica 2020 October;72(5):364-71

DOI: 10.23736/S0026-4946.20.05993-9

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

An update on biological therapies for pediatric allergic diseases

Riccardo CASTAGNOLI, Maria DE FILIPPO, Martina VOTTO, Alessia MARSEGLIA, Lorenza MONTAGNA, Gian Luigi MARSEGLIA ✉, Amelia LICARI

Department of Pediatrics, Pediatric Clinic, IRCCS San Matteo Polyclinic Foundation, University of Pavia, Pavia, Italy

Allergic diseases represent a global health burden. Patients with allergic diseases may experience disability, reduced quality of life and productivity, emotional distress, and social restrictions, especially in the most severe cases. Current advances in unveiling the pathogenesis of allergic disorders have paved the way for the development of novel therapeutic strategies. Biological drugs have been widely studied in pediatric allergic asthma, with strong evidence of efficacy and safety. Moreover, promising results derive from studies on other conditions such as atopic dermatitis, chronic spontaneous urticaria, and food allergy. This review analyzes recent evidence on the role of biologic therapies for allergic diseases, focusing on the pediatric age.

KEY WORDS: Child; Asthma; Chronic urticaria; Dermatitis, atopic; Food hypersensitivity