REVIEW   

Minerva Pediatrica 2020 April;72(2):116-22

DOI: 10.23736/S0026-4946.17.04823-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Recent perspectives of molecular aberrations in pediatric high-grade glioma

Zhengwei LI, Qingzeng SUN, Yingchun SHI ✉

Department of Pediatric Surgery, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou, China

Pediatric high-grade glioma (HGG), including diffuse intrinsic pontine glioma (DIPG) are highly aggressive tumors with no effective cures. Lack of understanding of the molecular biology of these tumors, in part due to lack of well-characterized pre-clinical models, is a great challenge in the development of novel therapies. Recent studies have shown that pediatric HGG short-term cell cultures retain many of the tumor characteristics in vivo and at present one of the best choices for in-vivo experimental studies. The present review article would put light on novel genetic and epigenetic changes in pediatric HGG that might, act as a gold standard potential biomarkers and/or therapeutic targets in near future.

KEY WORDS: Genetics; Biomarkers; Glioma