ORIGINAL ARTICLE   

Minerva Pediatrica 2019 October;71(5):449-54

DOI: 10.23736/S0026-4946.17.04268-2

Copyright © 2015 EDIZIONI MINERVA MEDICA

lingua: Inglese

Comparison of ferrous sulfate, polymaltose complex and iron-zinc in iron deficiency anemia

Yasemin OZSUREKCI ¹ ✉, Sule UNAL ², Mualla CETIN ², Fatma GUMRUK ²

¹ Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey; ² Department of Pediatric Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey

BACKGROUND: The purpose of this study was to compare the effectiveness of different oral iron preparations in children with iron deficiency anemia (IDA).
METHODS: Sixty children with IDA, aged between 6 months and 180 months, were randomly assigned into three treatment groups. Group I included children with IDA who received ferrous sulfate (Fe-S); Group II included children receiving iron polymaltose complexes (Fe-OH-PM), and Group III included children receiving a single preparation of combined iron and zinc (Fe-Zn). The effect of different iron preparations were evaluated and compared. The duration of treatment was 8 weeks. Hemoglobin (Hgb) levels, as well as other hematological parameters were determined at admission and the first, fourth, and eighth weeks of the treatment.
RESULTS: The Hgb levels of patients in all three groups were statistically higher in the fourth (P=0.001) and eighth (P<0.001) weeks compared to baseline; although there was no difference between the groups at the end of the treatment period (P>0.05).
CONCLUSIONS: Our results indicate that, Fe-OH-PM and Fe-Zn preparations may also be preferred as a choice like Fe-S for treatment of children with IDA.

KEY WORDS: Child; Anemia, iron-deficiency; Zinc, deficiency