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Minerva Pediatrica 2018 February;70(1):1-4

DOI: 10.23736/S0026-4946.16.04394-2

Copyright © 2015 EDIZIONI MINERVA MEDICA

lingua: Inglese

Allergen immunotherapy and respiratory infections in children: an encouraging experience

Salvatore BARBERI 1, Luca BERNARDO 1, Enza D’AURIA 2, Francesca FERRARA 1, Silvia TOSI 1, Cristoforo INCORVAIA 3, Serena BUTTAFAVA 4, Franco FRATI 4, Giorgio CIPRANDI 5

1 Department of Pediatrics, Fatebenefratelli Hospital, Milan, Italy; 2 Department of Pediatrics, San Paolo Hospital, Milan, Italy; 3 Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 4 Medical and Scientific Department, Stallergenes Italy, Milan, Italy; 5 Department of Medicine, IRCCS-Azienda Ospedaliera Universitaria San Martino, Genoa, Italy


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BACKGROUND: Allergic inflammation may promote respiratory infections (RI). House dust mite (HDM) sensitization is common in childhood. Allergen immunotherapy may cure allergy as it restores a physiological immune and clinical tolerance toward the causal allergen and exerts anti-inflammatory activity. This study retrospectively investigated whether 3 year high-dose HDM-sublingual immunotherapy (SLIT) could affect respiratory infections in children with allergic rhinitis.
METHODS: Globally, 33 HDM allergic children (18 males, mean age 9.3 years) were subdivided in 2 groups: 20 treated with symptomatic drugs alone (group 1) and 13 by high-dose SLIT, titrated in mcg of major allergens (group 2) for 3 years.
RESULTS: SLIT-treated children had significantly (P=0.01) less RI episodes (3.6) than symptomatically-treated children (5.4). In addition, SLIT-treated children had less fever (P<0.01) and took fewer medications, such as antibiotics (P<0.05) and fever-reducers (P<0.01), than symptomatically-treated children.
CONCLUSIONS: This preliminary study suggests that high-dose 3-year SLIT might lessen RI in allergic children.


KEY WORDS: Desensitization, immunologic - Respiratory tract infections - Mites - Children, sublingual immunotherapy

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