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Minerva Pediatrica 2020 Jul 20

DOI: 10.23736/S0026-4946.20.05993-9

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

An update on biological therapies for pediatric allergic diseases

Riccardo CASTAGNOLI, Maria DE FILIPPO, Martina VOTTO, Alessia MARSEGLIA, Lorenza MONTAGNA, Gian Luigi MARSEGLIA , Amelia LICARI

Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy


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Allergic diseases represent a global health burden. Patients with allergic diseases may experience disability, reduced quality of life and productivity, emotional distress, and social restrictions, in particular in the most severe cases. Current advances in unveiling the pathogenesis of allergic disorders have paved the way for the development of novel therapeutic strategies. Biological drugs have been widely studied in pediatric allergic asthma, with strong evidence of efficacy and safety. Moreover, promising results derive from studies on other conditions such as atopic dermatitis, chronic spontaneous urticaria, and food allergy. The review analyzes recent evidence on the role of biologic therapies for allergic diseases, focusing on the pediatric age.


KEY WORDS: Children; Biologics; Allergic diseases; Asthma; Chronic spontaneous urticaria; Atopic dermatitis; Food allergy

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