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Minerva Pediatrica 2018 Dec 03

DOI: 10.23736/S0026-4946.18.05396-3

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Prognostic significance of expression of Myogenin and OCT4 in glioma

Nuo ZHENG, Dongli ZHANG, Xiaoming LIU

Department of Pediatric Neurology, Xuzhou Children's Hospital, Xuzhou, Jiangsu, P.R. China


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BACKGROUND: Glioma is the most common extracranial solid tumor of children. The malignant (cancer) cells form in neural crest cell of the adrenal gland. In this study we investigate the expressions of Myogenin and OCT4 in Glioma which might be used as prognostic makers for this deteriorated disease.
METHODS: We used Quantitative Fluorescence PCR (QF-PCR), Enzyme-linked immunosorbent assay (ELISA), and Western-blotting to measure the expression level of Myogenin and OCT4 in surgical removed Glioma from 41 patients in our hospital.
RESULTS: Compared to the healthy children the expression of Myogenin and OCT4 was significantly increased in both mRNA and protein level in Glioma tumor cells. In addition, these expressions increased as glioma deterioration.
CONCLUSIONS: These findings suggesting the expression of Myogenin and Oct4 may be useful indicators for predicting the prognosis of children with glioma.


KEY WORDS: Myogenin - OCT4 - Glioma - Clinical treatment - Prognosis

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