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MINERVA PEDIATRICA

Rivista di Pediatria, Neonatologia, Medicina dell’Adolescenza
e Neuropsichiatria Infantile


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Minerva Pediatrica 2018 Apr 12

DOI: 10.23736/S0026-4946.18.04978-2

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Influence of pharmacokinetic/pharmacodynamic ratio on vancomycin treatment response in paediatric patients with Staphylococcus aureus bacteremia

Jesus RUIZ , Ana GARCÍA-ROBLES, María R. MARQUÉS, Maria J. COMPANY, Antonio SOLANA, Jose L. POVEDA

Pharmacy Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain


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BACKGROUND: Staphylococcus aureus is a frequent cause of hospital-acquired bacteremia in paediatrics patients. Vancomycin is the drug of choice for the treatment of methicillin-resistant strains, although treatment failure is frequently observed. Area under the curve (AUC) of plasma concentrations over the minimum inhibitory concentration (MIC) has been proposed as the best index to predict treatment response, although information about its clinical impact on paediatric patients is scarce. The objective of this study is to determine if early recovery of an AUC/MIC>400 mg*h/L for vancomycin in paediatric patients with S. aureus bacteremia is associated with clinical and microbiological treatment response.
METHODS: Retrospective observational study. Paediatric patients younger than 3 years with vancomycin-treated S. aureus bacteremia were included. The pharmacokinetic parameters were calculated from the vancomycin value obtained in the first 72 hours of treatment, assuming a bicompartmental model. A multivariate analysis was performed to analyze factors associated with early clinical response, treatment failure, microbiological response and 30-day mortality.
RESULTS: 51 patients with S. aureus bacteremia were included in the study. In 18 patients (35.3%), strains with a MIC higher than 1.0 mg/L were isolated, being in eight (15.7%) greater than 1.5 mg/L. 22 (43.1%) patients did not reach an estimated AUC/MIC>400 during the first 72 hours. A significant association was observed between attainment of an AUC/MIC>400 and early clinical response [OR:3.23(95%CI:1.07-12.03)]. No significant association was found between an AUC/MIC>400 and microbiological response or mortality.
CONCLUSIONS: An AUC/MIC>400 is associated with early response to vancomycin in paediatric patients with S. aureus bacteremia.


KEY WORDS: Staphylococcus aureus - Bacteremia - Vancomycin

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Publication History

Article first published online: April 12, 2018
Manuscript accepted: March 8, 2018
Manuscript revised: February 8, 2018
Manuscript received: April 21, 2017

Per citare questo articolo

Ruiz J, García-Robles A, Marqués MR, Company MJ, Solana A, Poveda JL. Influence of pharmacokinetic/pharmacodynamic ratio on vancomycin treatment response in paediatric patients with Staphylococcus aureus bacteremia. Minerva Pediatr 2018 Apr 12. DOI: 10.23736/S0026-4946.18.04978-2

Corresponding author e-mail

jrzrms@gmail.com