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MINERVA PEDIATRICA

Rivista di Pediatria, Neonatologia, Medicina dell’Adolescenza
e Neuropsichiatria Infantile


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Minerva Pediatrica 2017 Jun 22

DOI: 10.23736/S0026-4946.17.04823-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Recent perspectives of molecular aberrations in pediatric high-grade glioma

Zhengwei LI, Qingzeng SUN, Yingchun SHI

Department of Pediatric Surgery, Xuzhou Children's Hospital, Xuzhou, P.R. China


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Paediatric high-grade glioma (HGG), including diffuse intrinsic pontine glioma (DIPG) are highly aggressive tumours with no effective cures. Lack of understanding of the molecular biology of these tumours, in part due to lack of well-characterized pre-clinical models, is a great challenge in the development of novel therapies. Recent studies have shown that paediatric HGG short-term cell cultures retain many of the tumour characteristics in vivo and at present one of the best choices for in-vivo experimental studies. The present review article would put light on novel genetic and epigenetic changes in paediatric HGG that might, act as a gold standard potential biomarkers and/or therapeutic targets in near future.


KEY WORDS: Genetics - Biomarkers - High grade glioma

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Li Z, Sun Q, Shi Y. Recent perspectives of molecular aberrations in pediatric high-grade glioma. Minerva Pediatr 2017 Jun 22. DOI: 10.23736/S0026-4946.17.04823-X

Corresponding author e-mail

yingchunshi007@gmail.com