Home > Riviste > Minerva Pediatrica > Fascicoli precedenti > Minerva Pediatrica 2018 February;70(1) > Minerva Pediatrica 2018 February;70(1):51-8

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Publication history
Estratti
Per citare questo articolo

MINERVA PEDIATRICA

Rivista di Pediatria, Neonatologia, Medicina dell’Adolescenza
e Neuropsichiatria Infantile


Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,764


eTOC

 

REVIEW  


Minerva Pediatrica 2018 February;70(1):51-8

DOI: 10.23736/S0026-4946.17.04944-1

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Effect of inhaled nitric oxide on oxygen therapy, mechanical ventilation, and hypoxic respiratory failure

Dan L. STEWART 1 , Paul A. VOGEL 2, Brant JARRETT 2, Jim POTENZIANO 2

1 Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA; 2 Medical Affairs and Research and Development, Mallinckrodt Pharmaceuticals, Hampton, NJ, USA


PDF  


To assess the role of inhaled nitric oxide (iNO) in reducing the need for oxygen therapy, decreasing time on mechanical ventilatory support, and attenuating probability of hypoxic respiratory failure severity progression, we reviewed published reports of phase III iNO studies in neonates with hypoxic respiratory failure and pulmonary hypertension, as well as a novel post-hoc analysis of data from the Clinical Inhaled Nitric Oxide Research Group Initiative (CINRGI) study population not been previously reported. The post-hoc analysis of the CINRGI study showed that iNO shortens the duration of oxygen therapy versus placebo (17 vs. 34 days; P<0.05); the CINRGI retrospective analysis by Konduri et al. showed earlier administration of iNO (oxygenation index [OI] 15-25) yielded a 48% relative reduction vs. placebo in number of patients who progressed to OI≥30 (16.7% vs. 32.2%; P=0.002). Golombek and Young’s pooled analysis of phase III studies showed a rapid improvement in oxygenation after initiation of iNO therapy versus controls in each study, and a significant reduction in median ventilation duration (11 vs. 14 days; P=0.003). A study by Gonzalez et al. revealed that earlier iNO administration in infants with mild to moderate hypoxic respiratory failure (OI 10-30) resulted in a decreased duration of oxygen therapy versus placebo (11.5 vs. 18.0 days; P<0.03) and reduced the probability of developing severe hypoxic respiratory failure.


KEY WORDS: Hypoxia - Respiratory therapy - Nitric oxide - Oxygen inhalation therapy - Respiratory insufficiency

inizio pagina

Publication History

Issue published online: January 12, 2018
Article first published online: May 4, 2017
Manuscript accepted: March 30, 2017
Manuscript received: March 3, 2017

Per citare questo articolo

Stewart DL, Vogel PA, Jarrett B, Potenziano J. Effect of inhaled nitric oxide on oxygen therapy, mechanical ventilation, and hypoxic respiratory failure. Minerva Pediatr 2018;70:51-8. DOI: 10.23736/S0026-4946.17.04944-1

Corresponding author e-mail

dan.stewart@louisville.edu