REVIEW   

Minerva Ortopedica e Traumatologica 2017 December;68(4):216-9

DOI: 10.23736/S0394-3410.17.03833-4

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

The relationship of normal BMI and Dupuytren’s disease

Jacques H. HACQUEBORD ¹ ✉, Neil G. HARNESS ²

¹ Department of Orthopedic Surgery and Plastic Surgery, New York University, New York, NY, USA; ² Department of Orthopedic Surgery, Kraemer Medical Office 1, Kaiser Permanente Orange County, Anaheim, CA, USA

The risk of Dupuytren’s disease has long been established to be greatest in middle aged men of Northern European descent. It is now known though, that Dupuytren’s disease commonly affects patients of broader genetic backgrounds. Other risk factors for the development of Dupuytren’s and the progression of the disease have been studied, but findings remain controversial. More recently, the role of Body Mass Index (BMI) and Dupuytren’s disease diagnosis has been established. A recently published large and genetically diverse demographic study has established that normal BMI is a risk factor for diagnosis and that with increasing BMI the risk of Dupuytren’s disease significantly decreases. This opens up a very new and interesting avenue of research to further characterize the relationship between BMI and Dupuytren’s disease. Here follows a review of the current literature on this specific research area, possible explanations for this relationship, and future research.

KEY WORDS: Body Mass Index - Dupuytren contracture - Obesity