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Minerva Oftalmologica 2016 December;58(4):70-4


lingua: Inglese

Under-eye bags in healthy subjects: evaluation of the effects of a new escin-based cosmetic cream in an eight-week study

Gianni BELCARO 1, Mark DUGALL 1, Giada MARAMALDI 2, Stefano TOGNI 2, Luca GIACOMELLI 3

1 Department of SMO Biotech, Irvine3 Labs, Circulation Sciences, University of Chieti-Pescara, Chieti, Italy; 2 Indena SpA, Milan, Italy; 3 Department of Surgical Sciences and Integrated Diagnostics, School of Medicine, Genova University, Genoa, Italy


BACKGROUND: In order to find effective natural products to reduce under-eye bags, a multi-component formulation, containing escin as the main active ingredient has been tested in healthy subjects with lower eyelid bags.
METHODS: In this randomized, vehicle-controlled study, 57 healthy subjects with lower eyelid bags were advised to apply in the periorbital region and surrounding area, 1 g of the assigned formulation twice a day for 8 weeks. The three topical products used in this study were: vehicle (no active ingredients); escin 0.2% cream; a multi-component cream composed by escin β-sitosterol Phytosome® 1%, Zanthalene® 0.5%, Ximilene® 0.5%, Ruscogenins 0.1%. Esthetics and cosmetic parameters were evaluated at inclusion and after 4 and 8 weeks. Moreover, each subject gave a subjective evaluation of their lower eyelid appearance and their global facial appearance.
RESULTS: The 57 individuals recruited in this study were randomly assigned to either vehicle group (N.=18), escin 0.2% cream group (N.=19) or multicomponent cream group (N.=20). Significant improvements in the cosmetic and esthetic skin parameters of the lower eyelid area (infra-orbital hollow; skin moisture; skin content of water, oily substances and dead cells) were observed for the multicomponent cream-treated group. In addition, globally favorable were also the results of the subjective evaluations of the lower eyelid and global facial appearance in the group treated with the multicomponent cream.
CONCLUSIONS: Our study showed that the escin-based, multicomponent, topical cream is effective in reducing the lower eyelid bags appearance.

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