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ORIGINAL ARTICLE
Minerva Obstetrics and Gynecology 2022 August;74(4):330-6
DOI: 10.23736/S2724-606X.21.04888-0
Copyright © 2021 EDIZIONI MINERVA MEDICA
lingua: Inglese
Estrogen and progesterone receptors in endometriosis
Luiz R. GUIMARÃES FERREIRA 1, Teresa CAVALCANTI 2, Monica ZOMER 3, William KONDO 3, Edward ARAUJO JÚNIOR 4 ✉, Jaime KULAK JUNIOR 1
1 Department of Obstetrics and Gynecology, Federal University of Paraná (UFPR), Curitiba, Brazil; 2 Department of Pathology, Federal University of Paraná (UFPR), Curitiba, Brazil; 3 Advanced Gynecological Surgery Center, Reproduction Sector, Hospital Vita Batel, Curitiba, Brazil; 4 Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil
BACKGROUND: This study aims to identify the presence of estrogen and progesterone hormone receptors in endometriosis implants and to determine whether hormone treatment influences the receptors in these implants.
METHODS: Cross-sectional study with historical data collection. The analysis was conducted on 156 endometriosis implants from 67 patients undergoing endometriosis laparoscopy. The patients were divided into two groups: one group underwent hormone treatment (N.=20) and another group did not receive hormone treatment (N.=47) prior to surgery. Women of reproductive age with clinical pain and/or infertility who were diagnosed with endometriosis and underwent surgery were included. The specimens were analyzed after the estrogen and progesterone hormone receptors underwent immunohistochemistry.
RESULTS: All analyzed topographies presented estrogen and progesterone hormone receptors. Progesterone hormone receptor expression was considerably superior to estrogen receptor expression (P<0.001).
CONCLUSIONS: Hormone receptors are present in endometriosis implants on the ovarian fossae, uterosacral ligaments, sac fundus, and ovaries. Progesterone receptors predominate in implants, regardless of hormonal treatment.
KEY WORDS: Endometriosis; Estrogen receptors; Progesterone receptors