ORIGINAL ARTICLE   

Minerva Obstetrics and Gynecology 2022 February;74(1):60-7

DOI: 10.23736/S2724-606X.21.04750-3

Copyright © 2021 EDIZIONI MINERVA MEDICA

lingua: Inglese

Clinical and laboratory assessment of the role of the conditionally pathogenic sexually transmitted flora in the formation of the pathological state of the cervix and cervical canal in women of reproductive age

Azat R. ABDRAKHMANOV ^{1, 2, 3} ✉, Rasim M. ABDRAKHMANOV ³

¹ Reproductive Health Research Center, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia; ² University Kazan Clinic, Kazan Federal University, Kazan, Russia; ³ Department of Dermato-Venerology, Kazan State Medical University, Kazan, Russia

BACKGROUND: Inflammatory diseases of the pelvic organs, associated also with conditionally pathogenic flora, play a key role in the development of several pathological changes in the organs of the urogenital tract in women, including tumors, infertility, etc. Objective is to determine the role of conditionally pathogenic sexually transmitted infections in the formation of pathological conditions of the cervix in women of reproductive age.
METHODS: One hundred fifty-one patients aged 20-35 year participated in this cross-sectional study. These patients were examined with the use of a complex of clinical, laboratory and instrumental methods of examination. These women underwent a specific treatment. The next treatment regimen was administered: josamycin 500 mg orally 3 times a day for 10 days or doxycycline monohydrate 100 mg orally 2 times a day after a meal for 10 days.
RESULTS: Conditionally pathogenic sexually transmitted infection is widespread among women of reproductive age, accounting for 46.0%. In 88.7% of cases, the clinical manifestations are subjectively asymptomatic, i.e., the patient did not have any complaints, but 86.15% of them have various lesions of the cervix and cervical canal. Moreover, under the influence of opportunistic sexually transmitted infections, basic functional parameters of cervical mucus get worse significantly. This greatly reduces the quality of the reproductive function in these patients.
CONCLUSIONS: Providing proper diagnostic procedures and adequate and rational treatment of inflammatory diseases is a condition to prevent the development of pathological conditions of the cervix and cervical canal.

KEY WORDS: Urogenital system; Infections; Pelvic inflammatory disease; Genitalia; Infertility