Home > Riviste > Minerva Medica > Fascicoli precedenti > Articles online first > Minerva Medica 2020 Jul 22

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo

 

 

Minerva Medica 2020 Jul 22

DOI: 10.23736/S0026-4806.20.06801-9

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Methylenetetrahydrofolate reductase (MTHFR) C667T polymorphism and susceptibility to late-onset Alzheimer's disease in the Italian population. A systematic review and meta-analysis

Marco ZUIN 1, 2, Carlo CERVELLATI 2 , Alessandro TRENTINI 2, Loris RONCON 2, Patrizia GUASTI 1, Giovanni ZULIANI 1

1 Department of Morphology, Surgery & Experimental Medicine, University of Ferrara, Ferrara, Italy; 2 Department of Cardiology, Santa Maria delle Misericordia Hospital, Rovigo, Italy


PDF


BACKGROUND: This study is a meta-analysis of the published studies on the relationship between methylenetetrahydrofolate reductase (MTHFR) C667T polymorphism and the risk of lateonset Alzheimer’s disease (LOAD) in Italian cohorts.
METHODS: We conducted a search on the electronic databases PubMed/Medline, Web of Science and Scopus. All cohort and case-control studies investigating the association between MTHFR 677T polymorphism and LOAD in Italian population published any time to May 8, 2020 were included in the analysis.
RESULTS: From an initial screening of 136 articles, 4 were included into the systemic review. The pooled analysis based on the co-dominant model revealed that the MTHFR C677T polymorphism was associated with a significant risk of LOAD among Italian cohorts (TC vs. CC: OR=1.20, 95% CI=1.06-1.36, p=0.004, I2=0%). Conversely, the pooled analysis based on the allelic model demonstrated a non-significant relationship between the MTHFR C677T polymorphism and susceptibility to LOAD in Italians (OR: 1.25, 95% CI: 0.99-1.59, p=0.060, I2=14.6%). Moreover, Italian subjects with MTHFR 677TT genotype resulted to have a significantly increased susceptibility to LOAD (OR: 1.75, 95% CI:1.23-2.50, p=0.002, I2=0%).
CONCLUSIONS: The present meta-analysis showed only trend of association between MTHFR C677T polymorphism and LOAD in Italian population; however, it also demonstrated an increased susceptibility of LOAD in patients having MTHFR 677TT genotype. Further studies are needed to establish whether MTHFR polymorphisms can be used as non-invasive biomarker for LOAD.


KEY WORDS: Alzheimer’s disease; MTHFR; Meta-analysis; Polymorphisms

inizio pagina