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Minerva Medica 2020 Mar 12

DOI: 10.23736/S0026-4806.20.06447-2


lingua: Inglese

Emerging trends in cardiovascular research: HFpEF in the spotlight. A bibliometric analysis of the years 2009-2016

Christoph EDLINGER 1, 2, 3 , Tobias MÖSENLECHNER 3, Florian KRIZANIC 4, Bernhard WERNLY 3, Daniel KRETZSCHMAR 4, Uta C. HOPPE 3, Christian BUTTER 1, 2, Michael NEUSS 1, 2, Michel NOUTSIAS 6, Christina GRANITZ 3, Christiana SCHERNTHANER 3, Wilfried WINTERSTELLER 3, Michael LICHTENAUER 3

1 Department of Cardiology, Heart Center Brandenburg, Bernau/Berlin, Germany; 2 Brandenburg Medical School (MHB) "Theodor Fontane", Neuruppin, Germany; 3 Department of Cardiology, Clinic of Internal Medicine II, Paracelsus Medical University of Salzburg, Salzburg, Austria; 4 Department of Cardiology, Caritas Clinic Pankow Berlin, Berlin, Germany; 5 Clinic of Internal Medicine I, Friedrich Schiller University Jena, Jena, German; 6 Division of Cardiology, Angiology and Intensive Medical Care, Department of Internal Medicine III, Mid-German Heart Center, University Hospital Halle, Martin-Luther-University Halle, Halle, Germany


BACKGROUND: Up to 50% of patients suffering from acute decompensated heart failure show normal or slightly reduced left ventricular ejection fraction (LVEF). This syndrome, which is known as “heart failure with preserved ejection fraction” (HFpEF) is associated with increasing age. Epidemiological studies could portrait an increasing importance and an even emerging prevalence in the past decades. Still, there is currently no evidenced based medical treatment option available. Our aims were to identify upcoming trends and emerging concepts and to point out important centers in the global research of HFpEF.
METHODS: We performed a bibliometric study on current science in the field of HFpEF to identify study characteristics, impact factors and the countries of origin of basic and clinical studies that were published within the years 2009 to 2016. We further prepared density equalizing maps for visualization of the obtained data.
RESULTS: A total of 5413 studies was screened, of which 794 were found eligible. The scientific output in clinical studies rose from 25 in 2009 to 165 in 2016. Most of the publications had a clinical topic, followed by studies on new imaging techniques. Basic research trials were by far beyond. United States, Japan and Germany were identified as the most important national contributors to global scientific output.
CONCLUSIONS: This first bibliometric study in the field of HFpEF shows a substantial increase of research within the last decade, mainly in the United States, Japan, and continental Europe. As an onholding therapeutic trend in this field, we identified RAAS-blockade and 5- phosphodiesterase-inhibition.

KEY WORDS: HFpEF; Heart failure; Density equalizing maps; Bibliometric studies

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