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Minerva Medica 2019 May 06

DOI: 10.23736/S0026-4806.19.06109-3


lingua: Inglese

Non-invasive assessment of liver fibrosis in HCV patients compared to liver biopsy: the experience of tertiary level Hospital in Serbia

Tomislav PREVEDEN 1, 2, Benjamin VEREŠ 1, Maja RUŽIĆ 1, 2, Maria PETE 1, 2, Francesco LUZZA 3, Rinaldo PELLICANO 4, Ludovico ABENAVOLI 3

1 Clinical Center of Vojvodina, Clinic for Infectious Disease, Novi Sad, Serbia; 2 Medical Faculty, University of Novi Sad, Novi Sad, Serbia; 3 Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy; 4 Unit of Gastroenterology, Molinette Hospital, Turin, Italy


BACKGROUND: Chronic hepatitis C virus (HCV) infection, that is defined by active carriage of HCV RNA in the blood, is represents one of the major public health problems worldwide. In Serbia, the prevalence of anti-HCV positive persons in the general population, is estimated on average 1.13%.
METHODS: The aim of our study was to evaluate the ability of non-invasive scores in order to define the degree of liver fibrosis, and to assess the effect of host and viral factors on fibrosis in chronic HCV patients. In a retrospective analysis a total of 814 patients with chronic HCV infection were included. Liver fibrosis scores were calculated, and in particular AST/ALT score APRI, Forns index, and FIB-4 score, and all of them compared with histological classification. RESULTS: We found that non-invasive biochemical scores of fibrosis, have a good performance especially to distinguish mild and moderate fibrosis to advanced fibrosis. In particular, we found that FIB-4 score is an useful screening tool to accurately exclude patients with advanced disease.
CONCLUSIONS: Non-invasive liver fibrosis scores are efficient tools in the management and follow-up of HCV patients in clinical practice.

KEY WORDS: Liver disease - Diagnosis - Viral hepatitis - Vojvodina

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