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Minerva Medica 2017 Dec 04

DOI: 10.23736/S0026-4806.17.05496-9


lingua: Inglese

Diabetic nephropathy in type 1 diabetes

Nektaria PAPADOPOULOU-MARKETOU 1, 2 *, Stavroula A. PASCHOU 1, Nikolaos MARKETOS 3, Sofia ADAMIDI 4, Sotiris ADAMIDIS 4, Christina KANAKA-GANTENBEIN 1

1 Diabetes Centre of the Division of Endocrinology, Diabetes and Metabolism, First Department of Pediatrics, National and Kapodistrian University of Athens, Aghia Sophia Children’s Hospital, Athens, Greece; 2 Department of Endocrinology, Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden; 3 Department of Rheumatology, Medical Center of Athens, Athens, Greece 4 Department of Internal Medicine, Medical Center of Athens, Athens, Greece


Diabetic nephropathy (DN) also named diabetic kidney disease (DN) is one of the leading causes of mortality in people with diabetes. The aim of this review is to update the medical literature, the theories behind its early natural history, the pathways of its pathogenesis, its diagnosis and treatment. Poor glycemic control, hyperlipidemia, smoking, oxidative stress, accumulation of advanced glycated end products, environmental, genetic and epigenetic factors play an important role in the pathophysiological development of DN. Microalbuminuria has been traditionally used as the primary early diagnostic marker of microvascular complication unraveling the risk for progress to severe cardiorenal outcomes, but its prognostic role has been recently debated. The disease often leads to end-stage renal disease and it is often associated with major cardiovascular outcomes. Its early diagnosis is crucial for the patients in order to have a chance for proper treatment.

KEY WORDS: Diabetic nephropathy - Complications - Diabetes

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Publication History

Article first published online: December 04, 2017
Manuscript accepted: November 23, 2017
Manuscript received: November 16, 2017

Per citare questo articolo

Papadopoulou-Marketou N, Paschou SA, Marketos N, Adamidi S, Adamidis S, Kanaka-Gantenbein C. Diabetic nephropathy in type 1 diabetes. Minerva Med 2017 Dec 04. DOI: 10.23736/S0026-4806.17.05496-9

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