Home > Riviste > Minerva Medica > Fascicoli precedenti > Minerva Medica 2020 August;111(4) > Minerva Medica 2020 August;111(4):337-43

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo
Share

 

ORIGINAL ARTICLE   

Minerva Medica 2020 August;111(4):337-43

DOI: 10.23736/S0026-4806.20.06401-0

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Programmed death-ligand 1 expression and tumor-infiltrating lymphocytes in colorectal adenocarcinoma

Upik A. MISKAD , Nursakti HAMZAH, Muhammad H. CANGARA, Berti J. NELWAN, Rina MASADAH, Syarifuddin WAHID

Department of Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia



BACKGROUND: Programmed death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) are considered have a prognostic value in several malignancies. This study investigated the correlation between PD-L1 expression of tumor cells with the degree of stromal TILs in colorectal adenocarcinoma.
METHODS: A cross sectional study design performed by taking 52 colorectal adenocarcinoma samples. The specimens were stained by immunohistochemical procedure using PD-L1 rabbit monoclonal antibody and the degrees of TILs were assessed base on hematoxylin and eosin (H&E) staining.
RESULTS: From a total of 52 samples, the positive PD-L1 expression of tumor cells were 44 (84.6%) samples with 22 (50.0%), 18 (40.9%) and 4 (9.1%) samples had low-, moderate-, and high-degree TILs, respectively. While the negative PD-L1 expression were eight (15.4%) samples with 1 (12.5%), three (37.5%) and four (50.0%) samples had low-, moderate-, and high-degree TILs, respectively. A value of P=0.017 (P<0.05) was obtained by the Chi-square test.
CONCLUSIONS: This study concluded that there was a significant correlation between PD-L1 expression of tumor cells and the degree of TILs in colorectal adenocarcinoma. This result indicated that the degree of TILs had the potential to be used as a predictive factor for PD-L1 expression of tumor cells in colorectal adenocarcinoma.


KEY WORDS: Tumor-infiltrating lymphocytes; Colorectal neoplasms; Adenocarcinoma

inizio pagina