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Minerva Medica 2017 June;108(3):287-92

DOI: 10.23736/S0026-4806.16.04764-9


lingua: Inglese

miR-146a rs2910164 and hepatocellular carcinoma: a meta-analysis

Shu DONG 1, 2, Ai-Yu MIAO 2, 3, Wang LEI 4, Qi-Wen, CHEN 1, 5

1 Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China; 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; 3 Department of Ultrasound, Fudan University Shanghai Cancer Center, Shanghai, China; 4 Digestive Endoscopy Center, Department of Gastroenterology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China; 5 Institute of Clinical Epidemiology, Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai, China


INTRODUCTION: Single nucleotide polymorphism in miRNAs can alter its expression, thus can lead to the development of cancers. Many studies have explored the association between miR-146a rs2910164 (G>C) polymorphism and hepatocellular carcinoma (HCC) risk, but the results remains inconsistent. So, we performed this pooled analyses in order to get a precise result.
EVIDENCE ACQUISITION: Odds ratios (OR) with 95% confidence intervals (CI), calculated by STATA software, was used to determine whether miR-146a rs2910164 polymorphism contributes to the risk of HCC. A comprehensive literature search was conducted on PubMed, Embase, Web of Science, and China National Knowledge Infrastructure up to May 30, 2016.
EVIDENCE SYNTHESIS: A total of 14 studies including 5921 cases and 7005 controls were included in this meta-analysis. When all the eligible studies were pooled into this meta-analysis, the miR-146a rs2910164 was associated with a decreased risk of hepatocellular carcinoma (OR=0.90; 95% CI=0.82-0.98, P=0.01, allele model).
CONCLUSIONS: Our meta-analysis supports that the miR-146a rs2910164 polymorphism contributes to the risk of HCC from currently available evidence.

KEY WORDS: MIRN146 microRNA, human - Polymorphism, genetic - Carcinoma, hepatocellular - Meta-analysis

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