ORIGINAL ARTICLE   

Minerva Medica 2017 April;108(2):103-7

DOI: 10.23736/S0026-4806.16.04951-X

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Analysis of metabolism-related indicators and MTHFR gene polymorphism in patients with H-type hypertension

Zhi TANG ^{1, 2}, Ling XIAO ³, Ji-Qun WANG ³, Tao ZHANG ¹ ✉

¹ Department of Otolaryngology, First Affiliated Hospital of Jinan University, Guangzhou, China; ² Department of Otolaryngology, Affiliated Hospital of Southern Medical University, First People’s Hospital of Shunde, Shunde, China; ³ Department of Medicine, Affiliated Hospital of the First People’s Hospital of Shunde, Xingtan Hospital, Shunde, China

BACKGROUND: This study aims to analyze the polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene in patients with hypertension, and explore the correlation between H-type hypertension and metabolic biochemical indicators such as homocysteine (Hcy).
METHODS: One hundred patients with H-type hypertension and 100 patients with common hypertension were selected as the study subjects. Plasma Hcy and blood lipids, blood glucose, and other biochemical indicators were detected in the two groups. Then, the polymorphism of the MTHFR gene was compared between these two groups.
RESULTS: Hcy, uric acid (UA) and creatinine (Cr) levels in the H-type hypertension group were significantly higher than those of the common hypertension group (t=4.832-14.989, P<0.05). The T allele was predominant in the MTHFR 677C/T genotype frequency distribution in the H-type hypertension group, while the C allele was predominantly in the frequency distribution in the common hypertension group (P<0.05).
CONCLUSIONS: High levels of Hcy, UA and Cr are closely related to the occurrence of H-type hypertension. Homozygous mutant TT genotype of 677C/T of the MTHFR gene may be an important genetic factor of H-type hypertension.

KEY WORDS: Hypertension - Methylenetetrahydrofolate reductase (NADPH2) - Genetic polymorphism - Homocysteine